Article (Scientific journals)
Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease
Pereira, Sandro L.; Grossmann, Dajana; Delcambre, Sylvie et al.
2023In Current Opinion in Neurobiology, 80, p. 102720
Peer Reviewed verified by ORBi
 

Files


Full Text
1-s2.0-S0959438823000454-main.pdf
Publisher postprint (1.3 MB)
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Parkin; Parkinson's disease; Mitochondria; mtDNA; Metabolism; Inflammation; Mitophagy; Calcium; PINK1; Biogenesis
Abstract :
[en] Mutations in PRKN cause the second most common genetic form of Parkinson's disease (PD)—a debilitating movement disorder that is on the rise due to population aging in the industrial world. PRKN codes for an E3 ubiquitin ligase that has been well established as a key regulator of mitophagy. Together with PTEN-induced kinase 1 (PINK1), Parkin controls the lysosomal degradation of depolarized mitochondria. But Parkin's functions go well beyond mitochondrial clearance: the versatile protein is involved in mitochondria-derived vesicle formation, cellular metabolism, calcium homeostasis, mitochondrial DNA maintenance, mitochondrial biogenesis, and apoptosis induction. Moreover, Parkin can act as a modulator of different inflammatory pathways. In the current review, we summarize the latest literature concerning the diverse roles of Parkin in maintaining a healthy mitochondrial pool. Moreover, we discuss how these recent discoveries may translate into personalized therapeutic approaches not only for PRKN-PD patients but also for a subset of idiopathic cases.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Pereira, Sandro L.;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology Group
Grossmann, Dajana
Delcambre, Sylvie ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology
Hermann, Andreas
Grünewald, Anne  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology
External co-authors :
yes
Language :
English
Title :
Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease
Publication date :
2023
Journal title :
Current Opinion in Neurobiology
ISSN :
0959-4388
Publisher :
Elsevier, Netherlands
Volume :
80
Pages :
102720
Peer reviewed :
Peer Reviewed verified by ORBi
FnR Project :
FNR9631103 - Modelling Idiopathic Parkinson'S Disease-associated Somatic Variation In Dopaminergic Neurons, 2015 (01/01/2016-31/12/2022) - Anne Grünewald
Available on ORBilu :
since 06 May 2023

Statistics


Number of views
49 (0 by Unilu)
Number of downloads
21 (0 by Unilu)

Scopus citations®
 
6
Scopus citations®
without self-citations
6
WoS citations
 
7

Bibliography


Similar publications



Contact ORBilu