Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease

[en] Mutations in PRKN cause the second most common genetic form of Parkinson's disease (PD)—a debilitating movement disorder that is on the rise due to population aging in the industrial world. PRKN codes for an E3 ubiquitin ligase that has been well established as a key regulator of mitophagy. Together with PTEN-induced kinase 1 (PINK1), Parkin controls the lysosomal degradation of depolarized mitochondria. But Parkin's functions go well beyond mitochondrial clearance: the versatile protein is involved in mitochondria-derived vesicle formation, cellular metabolism, calcium homeostasis, mitochondrial DNA maintenance, mitochondrial biogenesis, and apoptosis induction. Moreover, Parkin can act as a modulator of different inflammatory pathways. In the current review, we summarize the latest literature concerning the diverse roles of Parkin in maintaining a healthy mitochondrial pool. Moreover, we discuss how these recent discoveries may translate into personalized therapeutic approaches not only for PRKN-PD patients but also for a subset of idiopathic cases.

Disciplines :

Biochimie, biophysique & biologie moléculaire

Auteur, co-auteur :

Pereira, Sandro L.; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology Group

Grossmann, Dajana

DELCAMBRE, Sylvie ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology

Hermann, Andreas

GRÜNEWALD, Anne ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology

Co-auteurs externes :

yes

Langue du document :

Anglais

Titre :

Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease

Date de publication/diffusion :

2023

Titre du périodique :

Current Opinion in Neurobiology

ISSN :

0959-4388

Maison d'édition :

Elsevier, Pays-Bas

Volume/Tome :

Pagination :

102720

Peer reviewed :

Peer reviewed vérifié par ORBi

URL complémentaire :

https://www.sciencedirect.com/science/article/pii/S0959438823000454

Projet FnR :

FNR9631103 - Modelling Idiopathic Parkinson'S Disease-associated Somatic Variation In Dopaminergic Neurons, 2015 (01/01/2016-31/12/2022) - Anne Grünewald

Disponible sur ORBilu :

depuis le 06 mai 2023

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Nombre de téléchargements

118 (dont 5 Unilu)

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Bibliographie

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