Article (Scientific journals)
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer.
Lacroix, Matthieu; Riscal, Romain; Arena, Giuseppe et al.
2020In Molecular Metabolism, 33, p. 2-22
Peer Reviewed verified by ORBi


Full Text
Lacroix et al, 2019.pdf
Publisher postprint (1.71 MB)

All documents in ORBilu are protected by a user license.

Send to


Keywords :
Energy Metabolism/genetics; Homeostasis/genetics; Humans; Metabolic Diseases/genetics/metabolism/pathology; Neoplasms/genetics/metabolism/pathology; Signal Transduction/genetics; Tumor Suppressor Protein p53/genetics/metabolism; Cancer; Metabolism; Normal tissue homeostasis; p53
Abstract :
[en] BACKGROUND: The TP53 gene is one of the most commonly inactivated tumor suppressors in human cancers. p53 functions during cancer progression have been linked to a variety of transcriptional and non-transcriptional activities that lead to the tight control of cell proliferation, senescence, DNA repair, and cell death. However, converging evidence indicates that p53 also plays a major role in metabolism in both normal and cancer cells. SCOPE OF REVIEW: We provide an overview of the current knowledge on the metabolic activities of wild type (WT) p53 and highlight some of the mechanisms by which p53 contributes to whole body energy homeostasis. We will also pinpoint some evidences suggesting that deregulation of p53-associated metabolic activities leads to human pathologies beyond cancer, including obesity, diabetes, liver, and cardiovascular diseases. MAJOR CONCLUSIONS: p53 is activated when cells are metabolically challenged but the origin, duration, and intensity of these stresses will dictate the outcome of the p53 response. p53 plays pivotal roles both upstream and downstream of several key metabolic regulators and is involved in multiple feedback-loops that ensure proper cellular homeostasis. The physiological roles of p53 in metabolism involve complex mechanisms of regulation implicating both cell autonomous effects as well as autocrine loops. However, the mechanisms by which p53 coordinates metabolism at the organismal level remain poorly understood. Perturbations of p53-regulated metabolic activities contribute to various metabolic disorders and are pivotal during cancer progression.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Lacroix, Matthieu
Riscal, Romain
Arena, Giuseppe ;  Gustave Roussy Cancer Campus, Villejuif, France > INSERM U1030
Linares, Laetitia Karine
Le Cam, Laurent
External co-authors :
Language :
Title :
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer.
Publication date :
Journal title :
Molecular Metabolism
Publisher :
Elsevier, Berlin, Germany
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
Commentary :
Copyright © 2019 The Authors. Published by Elsevier GmbH.. All rights reserved.
Available on ORBilu :
since 05 April 2023


Number of views
12 (0 by Unilu)
Number of downloads
1 (0 by Unilu)

Scopus citations®
Scopus citations®
without self-citations
WoS citations


Similar publications

Contact ORBilu