Biomonitoring of fast-elimination endocrine disruptors - Results from a 6-month follow up on human volunteers with repeated urine and hair collection.

Fäys, François; Hardy, Emilie M.; Palazzi, Paul; Haan, Serge; Beausoleil, Claire; Appenzeller, Brice

doi:10.1016/j.scitotenv.2021.146330

Article (Scientific journals)

Biomonitoring of fast-elimination endocrine disruptors - Results from a 6-month follow up on human volunteers with repeated urine and hair collection.

Fäys, François; Hardy, Emilie M.; Palazzi, Paul et al.

2021 • In The Science of the total environment, 778, p. 146330

Peer reviewed

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https://hdl.handle.net/10993/54728

DOI
10.1016/j.scitotenv.2021.146330

PubMed
34030378

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Keywords :

Biological Monitoring; Endocrine Disruptors; Environmental Exposure/analysis; Follow-Up Studies; Healthy Volunteers; Humans; Phthalic Acids; Biomarkers of exposure; Biomonitoring; Endocrine disruptor; Hair; Urine

Abstract :

[en] BACKGROUND: The assessment of human exposure to fast-elimination endocrine disruptors (ED) such as phthalates, bisphenols or pesticides is usually based on urinary biomarkers. The variability of biomarkers concentration, due to rapid elimination from the body combined with frequent exposure is however pointed out as a major limitation to exposure assessment. Other matrices such as hair, less sensitive to short-term variations in the exposure, have been proposed as possible alternatives. Nevertheless, no study compared the information obtained from hair and urine respectively in a follow-up allowing to assess biomarkers variability over time in these two matrices, and to compare the correlation between them. METHODS: In the present study, hair and urine samples were collected from 16 volunteers over a 6 months follow-up. All in all, 92 hair samples and 805 urines samples were collected and analyzed for the presence of 16 phthalate metabolites, 4 bisphenols and 8 pesticides/metabolites. RESULTS: All the biomarkers analyzed were detected in at least one of the two matrices. 21 biomarkers were more frequently detected in hair, 6 in urine, and 1 was equivalent. Biomarkers intraclass correlation coefficients (ICC) ranged from 0.1 to 0.8 (ten above 0.4) in hair, and from 0.09 to 0.51 in urine (two above 0.4). The concentrations of biomarkers in hair and urine were significantly correlated for only one compound. CONCLUSION: This study highlights the complexity of assessing exposure to fast-elimination ED and suggests considering with caution the specificity of the matrix in data interpretation. The results document the respective advantages and limitations of urine and hair, and provide new insight in the understanding of the information provided by these biological matrices and their relevance for the assessment of human exposure to fast elimination contaminants. CAPSULE: 92 hair and 805 urine samples collected from 16 volunteers over 6 months, tested for phthalate metabolites, bisphenols and pesticides. 19 biomarkers (in hair) and 24 (in urine) were detected in >50% of the samples.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Fäys, François

Hardy, Emilie M.

Palazzi, Paul

Haan, Serge ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

Beausoleil, Claire

Appenzeller, Brice ; Luxembourg Institute of Health > Department of Population Health

External co-authors :

yes

Language :

English

Title :

Biomonitoring of fast-elimination endocrine disruptors - Results from a 6-month follow up on human volunteers with repeated urine and hair collection.

Publication date :

2021

Journal title :

The Science of the total environment

ISSN :

0048-9697

eISSN :

1879-1026

Volume :

778

Pages :

146330

Peer reviewed :

Peer reviewed

FnR Project :

FNR11262468 - Novel Strategies For The Assessment Of Exposure To Fast Elimination Endocrine Disruptors With Non-invasive Biological Sampling, 2016 (01/10/2016-30/09/2020) - Francois Noel Marcel Josepha Fays

Funders :

FNR (AFR16 11262468) / ANSES (French Agency for Food, Environmental and Occupational Health & Safety)

Commentary :

Available on ORBilu :

since 29 March 2023

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