Article (Scientific journals)
Microglia states and nomenclature: A field at its crossroads.
Paolicelli, Rosa C.; Sierra, Amanda; Stevens, Beth et al.
2022In Neuron, 110 (21), p. 3458-3483
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Keywords :
Microglia
Abstract :
[en] Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
Disciplines :
Neurology
Author, co-author :
Paolicelli, Rosa C.
Sierra, Amanda
Stevens, Beth
Tremblay, Marie-Eve
Aguzzi, Adriano
Ajami, Bahareh
Amit, Ido
Audinat, Etienne
Bechmann, Ingo
Bennett, Mariko
Bennett, Frederick
Bessis, Alain
Biber, Knut
Bilbo, Staci
Blurton-Jones, Mathew
Boddeke, Erik
Brites, Dora
Brône, Bert
Brown, Guy C.
Butovsky, Oleg
Carson, Monica J.
Castellano, Bernardo
Colonna, Marco
Cowley, Sally A.
Cunningham, Colm
Davalos, Dimitrios
De Jager, Philip L.
de Strooper, Bart
Denes, Adam
Eggen, Bart J. L.
Eyo, Ukpong
Galea, Elena
Garel, Sonia
Ginhoux, Florent
Glass, Christopher K.
Gokce, Ozgun
Gomez-Nicola, Diego
González, Berta
Gordon, Siamon
Graeber, Manuel B.
Greenhalgh, Andrew D.
Gressens, Pierre
Greter, Melanie
Gutmann, David H.
Haass, Christian
Heneka, Michael  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Heppner, Frank L.
Hong, Soyon
Hume, David A.
Jung, Steffen
Kettenmann, Helmut
Kipnis, Jonathan
Koyama, Ryuta
Lemke, Greg
Lynch, Marina
Majewska, Ania
Malcangio, Marzia
Malm, Tarja
Mancuso, Renzo
Masuda, Takahiro
Matteoli, Michela
McColl, Barry W.
Miron, Veronique E.
Molofsky, Anna Victoria
Monje, Michelle
Mracsko, Eva
Nadjar, Agnes
Neher, Jonas J.
Neniskyte, Urte
Neumann, Harald
Noda, Mami
Peng, Bo
Peri, Francesca
Perry, V. Hugh
Popovich, Phillip G.
Pridans, Clare
Priller, Josef
Prinz, Marco
Ragozzino, Davide
Ransohoff, Richard M.
Salter, Michael W.
Schaefer, Anne
Schafer, Dorothy P.
Schwartz, Michal
Simons, Mikael
Smith, Cody J.
Streit, Wolfgang J.
Tay, Tuan Leng
Tsai, Li-Huei
Verkhratsky, Alexei
von Bernhardi, Rommy
Wake, Hiroaki
Wittamer, Valérie
Wolf, Susanne A.
Wu, Long-Jun
Wyss-Coray, Tony
More authors (86 more) Less
External co-authors :
yes
Language :
English
Title :
Microglia states and nomenclature: A field at its crossroads.
Publication date :
2022
Journal title :
Neuron
ISSN :
1097-4199
Publisher :
Cell Press, Cambridge, United States - Massachusetts
Volume :
110
Issue :
21
Pages :
3458-3483
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2022 Elsevier Inc. All rights reserved.
Available on ORBilu :
since 26 January 2023

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