[en] There is an urgent need to improve the understanding of neuroinflammation in Alzheimer's disease (AD). We analyzed cerebrospinal fluid inflammatory biomarker correlations to brain structural volume and longitudinal cognitive outcomes in the DELCODE study and in a validation cohort of the F.ACE Alzheimer Center Barcelona. We investigated whether respective biomarker changes are evident before onset of cognitive impairment. YKL-40; sTREM2; sAXL; sTyro3; MIF; complement factors C1q, C4, and H; ferritin; and ApoE protein were elevated in pre-dementia subjects with pathological levels of tau or other neurodegeneration markers, demonstrating tight interactions between inflammation and accumulating neurodegeneration even before onset of symptoms. Intriguingly, higher levels of ApoE and soluble TAM receptors sAXL and sTyro3 were related to larger brain structure and stable cognitive outcome at follow-up. Our findings indicate a protective mechanism relevant for intervention strategies aiming to regulate neuroinflammation in subjects with no or subjective symptoms but underlying AD pathology profile.
Disciplines :
Neurologie
Auteur, co-auteur :
Brosseron, Frederic
Maass, Anne
Kleineidam, Luca
Ravichandran, Kishore Aravind
González, Pablo García
McManus, Róisín M.
Ising, Christina
Santarelli, Francesco
Kolbe, Carl-Christian
Häsler, Lisa M.
Wolfsgruber, Steffen
Marquié, Marta
Boada, Mercè
Orellana, Adelina
de Rojas, Itziar
Röske, Sandra
Peters, Oliver
Cosma, Nicoleta-Carmen
Cetindag, Arda
Wang, Xiao
Priller, Josef
Spruth, Eike J.
Altenstein, Slawek
Schneider, Anja
Fliessbach, Klaus
Wiltfang, Jens
Schott, Björn H.
Bürger, Katharina
Janowitz, Daniel
Dichgans, Martin
Perneczky, Robert
Rauchmann, Boris-Stephan
Teipel, Stefan
Kilimann, Ingo
Goerss, Doreen
Laske, Christoph
Munk, Matthias H.
Düzel, Emrah
Yakupov, Renat
Dobisch, Laura
Metzger, Coraline D.
Glanz, Wenzel
Ewers, Michael
Dechent, Peter
Haynes, John Dylan
Scheffler, Klaus
Roy, Nina
Rostamzadeh, Ayda
Teunissen, Charlotte E.
Marchant, Natalie L.
Spottke, Annika
Jucker, Mathias
Latz, Eicke
Wagner, Michael
Mengel, David
Synofzik, Matthis
Jessen, Frank
Ramirez, Alfredo
Ruiz, Agustín
HENEKA, Michael ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; University of Massachusetts Medical School > Division of Infectious Diseases and Immunology > Professor
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