Maternal genetic risk for depression and child human capital

Menta, Giorgia; Lepinteur, Anthony; Clark, Andrew; Ghislandi, Simone; d'Ambrosio, Conchita

Reference : Maternal genetic risk for depression and child human capital


	Document type :	Scientific journals : Article
	Discipline(s) :	Business & economic sciences : Special economic topics (health, labor, transportation…)
	To cite this reference:	http://hdl.handle.net/10993/53617

Title :	Maternal genetic risk for depression and child human capital
Language :	English
Author, co-author :	Menta, Giorgia [Luxembourg Institute of Socio-Economic Research (LISER), Luxembourg]
	Lepinteur, Anthony [University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) >]
	Clark, Andrew [Paris School of Economics - CNRS, France and University of Luxembourg]
	Ghislandi, Simone [Bocconi University, Italy]
	d'Ambrosio, Conchita [University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) >]
Publication date :	2023
Journal title :	Journal of Health Economics
Publisher :	Elsevier
Volume :	87
Pages :	102718
Peer reviewed :	Yes
Audience :	International
ISSN :	0167-6296
e-ISSN :	1879-1646
City :	Amsterdam
Country :	Netherlands
Keywords :	[en] Maternal depression ; Human capital ; ALSPAC
Abstract :	[en] We here address the causal relationship between the maternal genetic risk for depression and child human capital using UK birth-cohort data. We find that an increase of one standard deviation (SD) in the maternal polygenic risk score for depression reduces their children’s cognitive and non-cognitive skill scores by 5 to 7% of a SD throughout adolescence. Our results are robust to a battery of sensitivity tests addressing, among others, concerns about pleiotropy and dynastic effects. Our Gelbach decomposition analysis suggests that the strongest mediator is genetic nurture (through maternal depression itself), with genetic inheritance playing only a marginal role.
Permalink :	http://hdl.handle.net/10993/53617

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