[en] Biological materials, such as the actin cytoskeleton, exhibit remarkable structural adaptability to various external stimuli by consuming different amounts of energy. In this Letter, we use methods from large deviation theory to identify a thermodynamic control principle for structural transitions in a model cytoskeletal network. Specifically, we demonstrate that biasing the dynamics with respect to the work done by nonequilibrium components effectively renormalizes the interaction strength between such components, which can eventually result in a morphological transition. Our work demonstrates how a thermodynamic quantity can be used to renormalize effective interactions, which in turn can tune structure in a predictable manner, suggesting a thermodynamic principle for the control of cytoskeletal structure and dynamics.
Disciplines :
Physics
Author, co-author :
Lamtyugina, Alexandra; Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA
Qiu, Yuqing; Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA ; James Franck Institute, University of Chicago, Chicago, Illinois 60637, USA
FODOR, Etienne ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS)
Dinner, Aaron R.; Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA ; James Franck Institute, University of Chicago, Chicago, Illinois 60637, USA
Vaikuntanathan, Suriyanarayanan; Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA ; James Franck Institute, University of Chicago, Chicago, Illinois 60637, USA
External co-authors :
yes
Language :
English
Title :
Thermodynamic Control of Activity Patterns in Cytoskeletal Networks
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