Nanosensor Location in the Human Circulatory System Based on Electric Circuit Representation of Vessels

Nanotechnologies are advancing precision medicine applications, enhancing the detection and treatment of diseases. Traveling through the human vessels, nanosensors are envisioned to locally detect and actuate on targets very efficiently. In this area, modeling the behavior of traveling nanosensors in the human circulatory system helps developing new mechanisms for medical treatments. This paper explores the accurate modeling of the concentration level of the flowing nanosensors in vessels. We use a Markov chain formulation to predict the stationary distribution of them in the variety of vessel segments. To evaluate the transition probabilities of the Markov chain, we compute the blood flow based on the representation of vessels through electric circuit components. The resulting study reveals the dynamics of the movement of nanosensors in the blood flow yielding further details on their concentration level along vessels.