Reference : Integration of external biomass reactions into existing metabolic models
E-prints/Working papers : Already available on another site
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/52225
Integration of external biomass reactions into existing metabolic models
English
Moscardo Garcia, Maria[University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Pires Pacheco, Maria Irene[University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Sauter, Thomas[University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
3-Aug-2022
Cold Spring Harbor Laboratory Press
No
[en] Currently, seven biomass objective functions have been defined in human metabolic reconstructions. The integration of published biomass reactions into alternative models can contribute to the prediction power of the model. Thus, in this work, we present a workflow to integrate reactions and biomass functions originating from several genome-scale reconstructions into models other than their home models. Additionally, a benchmark to identify the biomass that confers the highest prediction accuracy in terms of gene essentiality and growth predictions is provided.