Integration of external biomass reactions into existing metabolic models

Reference : Integration of external biomass reactions into existing metabolic models


	Document type :	E-prints/Working papers : Already available on another site
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/52225

Title :	Integration of external biomass reactions into existing metabolic models
Language :	English
Author, co-author :	Moscardo Garcia, Maria [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Pires Pacheco, Maria Irene [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Sauter, Thomas [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Publication date :	3-Aug-2022
Publisher :	Cold Spring Harbor Laboratory Press
Peer reviewed :	No
Abstract :	[en] Currently, seven biomass objective functions have been defined in human metabolic reconstructions. The integration of published biomass reactions into alternative models can contribute to the prediction power of the model. Thus, in this work, we present a workflow to integrate reactions and biomass functions originating from several genome-scale reconstructions into models other than their home models. Additionally, a benchmark to identify the biomass that confers the highest prediction accuracy in terms of gene essentiality and growth predictions is provided.
Permalink :	http://hdl.handle.net/10993/52225
source URL :	https://www.biorxiv.org/content/10.1101/2022.08.01.502323v1

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