Article (Scientific journals)
I-GWAS: Privacy-Preserving Interdependent Genome-Wide Association Studies
Pascoal, Túlio; Decouchant, Jérémie; Boutet, Antoine et al.
2023In Proceedings on Privacy Enhancing Technologies
Peer reviewed
 

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Keywords :
Interdependent privacy; Genomic Privacy; Federated GWASes
Abstract :
[en] Genome-wide Association Studies (GWASes) identify genomic variations that are statistically associated with a trait, such as a disease, in a group of individuals. Unfortunately, careless sharing of GWAS statistics might give rise to privacy attacks. Several works attempted to reconcile secure processing with privacy-preserving releases of GWASes. However, we highlight that these approaches remain vulnerable if GWASes utilize overlapping sets of individuals and genomic variations. In such conditions, we show that even when relying on state-of-the-art techniques for protecting releases, an adversary could reconstruct the genomic variations of up to 28.6% of participants, and that the released statistics of up to 92.3% of the genomic variations would enable membership inference attacks. We introduce I-GWAS, a novel framework that securely computes and releases the results of multiple possibly interdependent GWASes. I-GWAS continuously releases privacy-preserving and noise-free GWAS results as new genomes become available.
Disciplines :
Computer science
Author, co-author :
Pascoal, Túlio ;  University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT) > CritiX
Decouchant, Jérémie;  TU Delft
Boutet, Antoine;  University of Lyon > INSA, INRIA
Volp, Marcus  ;  University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT) > CritiX
External co-authors :
yes
Language :
English
Title :
I-GWAS: Privacy-Preserving Interdependent Genome-Wide Association Studies
Publication date :
July 2023
Journal title :
Proceedings on Privacy Enhancing Technologies
Peer reviewed :
Peer reviewed
Focus Area :
Security, Reliability and Trust
Available on ORBilu :
since 31 August 2022

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