Reference : The Next Frontier of Environmental Unknowns: Substances of Unknown or Variable Compos...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Physical, chemical, mathematical & earth Sciences : Earth sciences & physical geography
Computational Sciences; Sustainable Development
The Next Frontier of Environmental Unknowns: Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs)
Lai, Adelene mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Environmental Cheminformatics > ; Friedrich-Schiller-University Jena > Institute for Inorganic and Analytical Chemistry]
Clark, Alex mailto [Collaborative Drug Discovery]
Escher, Beate mailto [Helmholtz Centre for Environmental Research GmbH─UFZ > > > ; Eberhard Karls University Tübingen > Environmental Toxicology, Center for Applied Geosciences]
Fernandez, Marc mailto [Environment and Climate Change Canada]
McEwen, Leah mailto [Cornell University > > > ; International Union of Pure and Applied Chemistry]
Tian, Zhenyu mailto [Northeastern University > Department of Chemistry and Chemical Biology, Department of Marine and Environmental Sciences]
Wang, Zhanyun mailto [Swiss Federal Laboratories for Materials Science and Technology > Technology and Society Laboratory > > ; ETH Zurich > Institute of Environmental Engineering, Chair of Ecological Systems Design]
Schymanski, Emma mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Environmental Cheminformatics >]
Environmental Science and Technology
American Chemical Society
Yes (verified by ORBilu)
[en] Mixtures ; Testing and Assessment ; Toxicity ; Chemical structure ; Cheminformatics ; Fossil fuels ; Science Policy ; Exposure ; Environmental Pollution
[en] Substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) are over 70 000 “complex” chemical mixtures produced and used at significant levels worldwide. Due to their unknown or variable composition, applying chemical assessments originally developed for individual compounds to UVCBs is challenging, which impedes sound management of these substances. Across the analytical sciences, toxicology, cheminformatics, and regulatory practice, new approaches addressing specific aspects of UVCB assessment are being developed, albeit in a fragmented manner. This review attempts to convey the “big picture” of the state of the art in dealing with UVCBs by holistically examining UVCB characterization and chemical identity representation, as well as hazard, exposure, and risk assessment. Overall, information gaps on chemical identities underpin the fundamental challenges concerning UVCBs, and better reporting and substance characterization efforts are needed to support subsequent chemical assessments. To this end, an information level scheme for improved UVCB data collection and management within databases is proposed. The development of UVCB testing shows early progress, in line with three main methods: whole substance, known constituents, and fraction profiling. For toxicity assessment, one option is a whole-mixture testing approach. If the identities of (many) constituents are known, grouping, read across, and mixture toxicity modeling represent complementary approaches to overcome data gaps in toxicity assessment. This review highlights continued needs for concerted efforts from all stakeholders to ensure proper assessment and sound management of UVCBs.
Fonds National de la Recherche - FnR ; National Institutes of Health ; European Union ; NCCR Catalysis
Researchers ; Professionals ; Students ; General public
H2020 ; 101036756 - ZeroPM - Zero Pollution of Persistent, Mobile Substances
FnR ; FNR12341006 > Emma Schymanski > ECHIDNA > Environmental Cheminformatics To Identify Unknown Chemicals And Their Effects > 01/10/2018 > 30/09/2023 > 2018

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