[en] Translation of specific mRNAs can be highly regulated in different cells, tissues or under pathological conditions. Ribosome heterogeneity can originate from variable expression or post-translational modifications of ribosomal proteins. The ribosomal oxygenases RIOX1 (NO66) and RIOX2 (MINA53) modify ribosomal proteins by histidine hydroxylation. A similar mechanism is present in prokaryotes. Thus, ribosome hydroxylation may be a well-conserved regulatory mechanism with implications in disease and development. However, little is known about the evolutionary history of Riox1 and Riox2 genes and their encoded proteins across eukaryotic taxa.
Disciplines :
Genetics & genetic processes
Author, co-author :
Braeuer, Katharina
Brockers, Kevin
Moneer, Jasmin
Feuchtinger, Annette
Wollscheid-Lengeling, Evi ; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
Lengeling, Andreas
Wolf, Alexander
External co-authors :
yes
Language :
English
Title :
Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution