Reference : Emulating the gut–liver axis: Dissecting the microbiome's effect on drug metabolism u...
Scientific journals : Article
Life sciences : Microbiology
http://hdl.handle.net/10993/49398
Emulating the gut–liver axis: Dissecting the microbiome's effect on drug metabolism using multiorgan-on-chip models
English
Lucchetti, Mara mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
Kaminska, Mathilda [Jena University Hospital]
Kehinde Oluwasegun, Aina [Jena University Hospital]
Mosig, Alexander [Jena University Hospital]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
Jun-2021
Current Opinion in Endocrine and Metabolic Research
Yes
[en] Drug metabolism ; Gut–liver axis ; Gut microbiome
[en] The homeostatic relationship between the gut, its microbiome, and the liver is crucial for the regulation of drug metabolism processes. Gut microbes are known to influence human health and disease by enhancing food metabolism and providing a first line of defense against pathogens. In addition to this, the gut microbiome also plays a key role in the processing of exogenous pharmaceutical compounds. Modeling the highly variable luminal gut environment and understanding how gut microbes can modulate drug availability or induce liver toxicity remains a challenge. However, microfluidics-based technologies such as organ-on-chips could overcome current challenges in drug toxicity assessment assays because these technologies are able to better recapitulate complex human responses. Efforts are being made to create in vitro multiorgan platforms, tailored for an individual patient's microbial background. These platforms could be used as a tool to predict the effect of the gut microbiome on pharmacokinetics in a personalized way.
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/49398
10.1016/j.coemr.2021.03.003
H2020 ; 812954 - EUROoC - Interdisciplinary training network for advancing Organ-on-a-chip technology in Europe

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