[en] We propose a model for the dynamics of a probe embedded in a living cell, where both thermal fluctuations and nonequilibrium activity coexist. The model is based on a confining harmonic potential describing the elastic cytoskeletal matrix, which undergoes random active hops as a result of the nonequilibrium rearrangements within the cell. We describe the probe's statistics and we bring forth quantities affected by the nonequilibrium activity. We find an excellent agreement between the predictions of our model and experimental results for tracers inside living cells. Finally, we exploit our model to arrive at quantitative predictions for the parameters characterizing nonequilibrium activity such as the typical time scale of the activity and the amplitude of the active fluctuations. Copyright (C) EPLA, 2015
Disciplines :
Physics
Author, co-author :
Fodor, Etienne ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS)
Guo, M.; School of Engineering and Applied Sciences, Harvard University - Cambridge, MA 02138, USA
Gov, N. S.; Department of Chemical Physics, Weizmann Institute of Science - 76100 Rehovot, Israel
Visco, P.; Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS/P7, Université Paris Diderot 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France
Weitz, D. A.; School of Engineering and Applied Sciences, Harvard University - Cambridge, MA 02138, USA
van Wijland, F.; Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS/P7, Université Paris Diderot 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France
External co-authors :
yes
Language :
English
Title :
Activity-driven fluctuations in living cells
Publication date :
2015
Journal title :
EPL
ISSN :
0295-5075
Publisher :
EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY, 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE, Unknown/unspecified
