Reference : Active cell mechanics: Measurement and theory
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
Physics and Materials Science
http://hdl.handle.net/10993/47929
Active cell mechanics: Measurement and theory
English
Ahmed, Wylie W. [Institut Curie, Centre de recherche, 11, rue Pierre et Marie Curie, 75005 Paris, France > > > ; Sorbonne Universités, Université Pierre et Marie Curie, Paris, France > > > ; Centre National de la Recherche Scientifique, UMR168, Paris, France]
Fodor, Etienne mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS)]
Betz, Timo [Institut Curie, Centre de recherche, 11, rue Pierre et Marie Curie, 75005 Paris, France > > > ; Sorbonne Universités, Université Pierre et Marie Curie, Paris, France > > > ; Centre National de la Recherche Scientifique, UMR168, Paris, France]
2015
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
ELSEVIER SCIENCE BV
1853
11, B, SI
3083-3094
Yes (verified by ORBilu)
International
0167-4889
PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
[en] Cell mechanics; Nonequilibrium biophysics; Force measurement Generalized Langevin Equation CONCENTRATED ISOTROPIC SOLUTIONS; SINGLE-PARTICLE TRACKING; OPTICAL TWEEZERS; SEMIFLEXIBLE POLYMERS; NONLINEAR ELASTICITY; VISCOELASTIC MODULI; PHYSICAL RESPONSES; LIVING CELLS; FORCE; MICRORHEOLOGY Biochemistry Molecular Biology; Cell Biology Biochemistry Molecular Biology; Cell Biology wylie.ahmed@gmail.com Fodor ; Etienne/O-1660-2019 Fodor ; Etienne/0000-0003-1372-2195 Betz ; Timo/0000-0002-1548-0655 Ahmed ; Wylie/0000-0001-5243-5864 La Fondation Pierre-Gilles de Gennes; Marie Curie ActionsEuropean Commission; French Agence Nationale de la Recherche (ANR)French National Research Agency (ANR) [ANR-11-JSV5-0002]; Lab Ex CelTisPhyBio grant [ANR-10-LBX-0038] We thank Paolo Visco and Frederic van Wijland for their helpful discussions. WWA is a recipient of post-doctoral fellowships from La Fondation Pierre-Gilles de Gennes and Marie Curie Actions. TB was supported by the French Agence Nationale de la Recherche (ANR) grant ANR-11-JSV5-0002 and Lab Ex CelTisPhyBio grant No. ANR-10-LBX-0038. 133 35 0 76 Biochim. Biophys. Acta-Mol. Cell Res. CT8LX WOS:000363069200013
[en] Living cells are active mechanical systems that are able to generate forces. Their structure and shape are primarily determined by biopolymer filaments and molecular motors that form the cytoskeleton. Active force generation requires constant consumption of energy to maintain the nonequilibrium activity to drive organization and transport processes necessary for their function. To understand this activity it is necessary to develop new approaches to probe the underlying physical processes. Active cell mechanics incorporates active molecular-scale force generation into the traditional framework of mechanics of materials. This review highlights recent experimental and theoretical developments towards understanding active cell mechanics. We focus primarily on intracellular mechanical measurements and theoretical advances utilizing the Langevin framework. These developing approaches allow a quantitative understanding of nonequilibrium mechanical activity in living cells. This article is part of a Special Issue entitled: Mechanobiology. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
http://hdl.handle.net/10993/47929
10.1016/j.bbamcr.2015.05.022
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