Reference : Deterministic Limit of Intracellular Calcium Spikes
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
Deterministic Limit of Intracellular Calcium Spikes
Voorsluijs, Valerie mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit]
Ponce Dawson, S. [> >]
De Decker, Y. [> >]
Dupont, G. [> >]
Physical Review Letters
American Physical Society
Yes (verified by ORBilu)
[en] In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism.

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