Article (Scientific journals)
Deterministic Limit of Intracellular Calcium Spikes
Voorsluijs, Valerie; Ponce Dawson, S.; De Decker, Y. et al.
2019In Physical Review Letters, 122 (8), p. 088101
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Abstract :
[en] In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Voorsluijs, Valerie  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
Ponce Dawson, S.
De Decker, Y.
Dupont, G.
External co-authors :
yes
Language :
English
Title :
Deterministic Limit of Intracellular Calcium Spikes
Publication date :
2019
Journal title :
Physical Review Letters
ISSN :
1079-7114
Publisher :
American Physical Society
Volume :
122
Issue :
8
Pages :
088101
Peer reviewed :
Peer Reviewed verified by ORBi
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