Article (Scientific journals)
Climate change and epilepsy: Insights from clinical and basic science studies
Gulcebi, Medine I.; Bartolini, Emanuele; Lee, Omay et al.
2021In Epilepsy and Behavior, 116, p. 107791
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Keywords :
Global warming; Emergency; Seizure; Temperature; Extreme weather events; Public health
Abstract :
[en] Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment. This review aimed to collate and evaluate reports from clinical and basic science about the relationship between climate change and epilepsy. The keywords climate change, seasonal variation, temperature, humidity, thermoregulation, biorhythm, gene, circadian rhythm, heat, and weather were used to search the published evidence. A number of climatic variables are associated with increased seizure frequency in people with epilepsy. Climate change-induced increase in seizure precipitants such as fevers, stress, and sleep deprivation (e.g. as a result of more frequent extreme weather events) or vector-borne infections may trigger or exacerbate seizures, lead to deterioration of seizure control, and affect neurological, cerebrovascular, or cardiovascular comorbidities and risk of sudden unexpected death in epilepsy. Risks are likely to be modified by many factors, ranging from individual genetic variation and temperature-dependent channel function, to housing quality and global supply chains. According to the results of the limited number of experimental studies with animal models of seizures or epilepsy, different seizure types appear to have distinct susceptibility to seasonal influences. Increased body temperature, whether in the context of fever or not, has a critical role in seizure threshold and seizure-related brain damage. Links between climate change and epilepsy are likely to be multifactorial, complex, and often indirect, which makes predictions difficult. We need more data on possible climate-driven altered risks for seizures, epilepsy, and epileptogenesis, to identify underlying mechanisms at systems, cellular, and molecular levels for better understanding of the impact of climate change on epilepsy. Further focussed data would help us to develop evidence for mitigation methods to do more to protect people with epilepsy from the effects of climate change.
Disciplines :
Neurology
Author, co-author :
Gulcebi, Medine I.
Bartolini, Emanuele
Lee, Omay
Lisgaras, Christos Panagiotis
Onat, Filiz
Mifsud, Janet
Striano, Pasquale
Vezzani, Annamaria
Hildebrand, Michael S.
Jimenez-Jimenez, Diego
Junck, Larry
Lewis-Smith, David
Scheffer, Ingrid E.
Thijs, Roland D.
Zuberi, Sameer M.
Blenkinsop, Stephen
Fowler, Hayley J.
Foley, Aideen
Balestrini, Simona
Berkovic, Samuel
Cavalleri, Gianpiero
Correa, Daniel José
Custodio, Helena Martins
Galovic, Marian
Guerrini, Renzo
Henshall, David
Howard, Olga
Hughes, Kelvin
Katsarou, Anna
Koeleman, Bobby P. C.
KRAUSE, Roland  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Lowenstein, Daniel
Mandelenaki, Despoina
Marini, Carla
O'Brien, Terence J.
Pace, Adrian
Palma, Luca De
Perucca, Piero
Pitkänen, Asla
Quinn, Finola
Selmer, Kaja Kristine
Steward, Charles A.
Swanborough, Nicola
Thijs, Roland
Tittensor, Phil
Trivisano, Marina
Weckhuysen, Sarah
Zara, Federico
Sisodiya, Sanjay M.;  University College London - UCL
More authors (39 more) Less
External co-authors :
yes
Language :
English
Title :
Climate change and epilepsy: Insights from clinical and basic science studies
Publication date :
2021
Journal title :
Epilepsy and Behavior
ISSN :
1525-5050
Volume :
116
Pages :
107791
Peer reviewed :
Peer reviewed
Focus Area :
Systems Biomedicine
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since 18 February 2021

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