Reference : Cardiovascular effects of Org 9487 under isoflurane anaesthesia in man
Scientific journals : Article
Social & behavioral sciences, psychology : Animal psychology, ethology & psychobiology
Social & behavioral sciences, psychology : Neurosciences & behavior
Social & behavioral sciences, psychology : Theoretical & cognitive psychology
Social & behavioral sciences, psychology : Treatment & clinical psychology
Human health sciences : Psychiatry
Cardiovascular effects of Org 9487 under isoflurane anaesthesia in man
Osmer, Christian [> >]
Wulf, Kay [> >]
Vögele, Claus mailto [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE) >]
Zickmann, Bernfried [> >]
Hempelmann, Gunther [> >]
European Journal of Anaesthesiology
Cambridge University Press
Yes (verified by ORBilu)
United Kingdom
[en] Neuromuscular relaxant ; Org 9487 ; Cardiovascular effects
[en] The cardiovascular effects of Org 9487 during isoflurane anaesthesia have been evaluated using three doses around its ED90 for neuromuscular blockade, i.e. 1 mg kg-1, 2 mg kg-1 and 3 mg kg-1. Heart rate increased to 110%, 115% and 118% in patients receiving 1 mg kg-1, 2 mg kg-1 and 3 mg kg-1 respectively. There were no significant effects on systolic and diastolic blood pressures for the two lower dose groups. Patients receiving Org 9487 3 mg kg-1 displayed significant decreases in systolic and diastolic blood pressures (91% and 82% of the control values respectively). Except for heart rate in the group receiving 3 mg kg-1, all measurements returned to baseline after a maximum of 15 min. Six patients experienced a transient increase in airway pressure after administration of Org 9487, which was accompanied by a decrease in oxygen saturation in two out of six subjects, but there was no audible wheezing. These episodes were self-limiting and required no treatment. There were no other adverse reactions to this drug during this study.
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