Reference : Cross-sectional focusing of red blood cells in a constricted microfluidic channel
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Physical, chemical, mathematical & earth Sciences : Physics
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/10993/45604
Cross-sectional focusing of red blood cells in a constricted microfluidic channel
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Abay, Asena [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.]
Recktenwald, Steffen M. [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.]
John, Thomas [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.]
Kaestner, Lars [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.]
Wagner, Christian mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit]
2020
SOFT MATTER
Royal Soc Chemistry
16
2
534-543
Yes
1744-683X
Cambridge
[en] Constrictions in blood vessels and microfluidic devices can dramatically change the spatial distribution of passing cells or particles and are commonly used in biomedical cell sorting applications. However, the three-dimensional nature of cell focusing in the channel cross-section remains poorly investigated. Here, we explore the cross-sectional distribution of living and rigid red blood cells passing a constricted microfluidic channel by tracking individual cells in multiple layers across the channel depth and across the channel width. While cells are homogeneously distributed in the channel cross-section pre-contraction, we observe a strong geometry-induced focusing towards the four channel faces post-contraction. The magnitude of this cross-sectional focusing effect increases with increasing Reynolds number for both living and rigid red blood cells. We discuss how this non-uniform cell distribution downstream of the contraction results in an apparent double-peaked velocity profile in particle image velocimetry analysis and show that trapping of red blood cells in the recirculation zones of the abrupt construction depends on cell deformability.
Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [DFG FOR 2688 WA 1336/13-1] ; European Framework 'Horizon 2020' [675115] ; Volkswagen FoundationVolkswagen [Az: 93839]
http://hdl.handle.net/10993/45604
10.1039/c9sm01740b
The research leading to these results has received funding from the Deutsche Forschungsgemeinschaft DFG FOR 2688 WA 1336/13-1, from the European Framework 'Horizon 2020' under grant agreement number 675115 (RELEVANCE) and from the Volkswagen Foundation (Az: 93839).

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