Reference : Cross-sectional focusing of red blood cells in a constricted microfluidic channel |
Scientific journals : Article | |||
Physical, chemical, mathematical & earth Sciences : Chemistry Physical, chemical, mathematical & earth Sciences : Physics Engineering, computing & technology : Materials science & engineering | |||
http://hdl.handle.net/10993/45604 | |||
Cross-sectional focusing of red blood cells in a constricted microfluidic channel | |
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Abay, Asena [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
Recktenwald, Steffen M. [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
John, Thomas [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
Kaestner, Lars [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
Wagner, Christian ![]() | |
2020 | |
SOFT MATTER | |
Royal Soc Chemistry | |
16 | |
2 | |
534-543 | |
Yes | |
1744-683X | |
Cambridge | |
[en] Constrictions in blood vessels and microfluidic devices can dramatically change the spatial distribution of passing cells or particles and are commonly used in biomedical cell sorting applications. However, the three-dimensional nature of cell focusing in the channel cross-section remains poorly investigated. Here, we explore the cross-sectional distribution of living and rigid red blood cells passing a constricted microfluidic channel by tracking individual cells in multiple layers across the channel depth and across the channel width. While cells are homogeneously distributed in the channel cross-section pre-contraction, we observe a strong geometry-induced focusing towards the four channel faces post-contraction. The magnitude of this cross-sectional focusing effect increases with increasing Reynolds number for both living and rigid red blood cells. We discuss how this non-uniform cell distribution downstream of the contraction results in an apparent double-peaked velocity profile in particle image velocimetry analysis and show that trapping of red blood cells in the recirculation zones of the abrupt construction depends on cell deformability. | |
Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [DFG FOR 2688 WA 1336/13-1] ; European Framework 'Horizon 2020' [675115] ; Volkswagen FoundationVolkswagen [Az: 93839] | |
http://hdl.handle.net/10993/45604 | |
10.1039/c9sm01740b | |
The research leading to these results has received funding from the Deutsche Forschungsgemeinschaft DFG FOR 2688 WA 1336/13-1, from the European Framework 'Horizon 2020' under grant agreement number 675115 (RELEVANCE) and from the Volkswagen Foundation (Az: 93839). |
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