Reference : Towards the routine use of in silico screenings for drug discovery using metabolic mo...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/43079
Towards the routine use of in silico screenings for drug discovery using metabolic modelling
English
Bintener, Tamara Jean Rita mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Pires Pacheco, Maria Irene mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Sauter, Thomas mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
5-May-2020
Biochemical Society Transactions
Portland Press
Yes (verified by ORBilu)
International
0300-5127
1470-8752
London
United Kingdom
[en] Metabolic Modelling ; drug repositioning ; cancer ; drug target discovery ; personalized medicine ; systems biology
[en] Currently, the development of new effective drugs for cancer therapy is not only hindered by development costs, drug efficacy, and drug safety but also by the rapid occurrence of drug resistance in cancer. Hence, new tools are needed to study the underlying mechanisms in cancer. Here, we discuss the current use of metabolic modelling approaches to identify cancer-specific metabolism and find possible new drug targets and drugs for repurposing. Furthermore, we list valuable resources that are needed for the reconstruction of cancer-specific models by integrating various available datasets with genome-scale metabolic reconstructions using model-building algorithms. We also discuss how new drug targets can be determined by using gene essentiality analysis, an in silico method to predict essential genes in a given condition such as cancer and how synthetic lethality studies could greatly benefit cancer patients by suggesting drug combinations with reduced side effects.
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/10993/43079
10.1042/BST20190867
https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20190867/223815/Towards-the-routine-use-of-in-silico-screenings

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