Reference : Organized Management of Diabetes Mellitus in Lung Transplantation: Study of Glycemic ...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Surgery
	To cite this reference:	http://hdl.handle.net/10993/42782

Title :	Organized Management of Diabetes Mellitus in Lung Transplantation: Study of Glycemic Control and Patient Survival in a Single Center
Language :	English
Author, co-author :	Riou, Marianne [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program,]
	Renaud-Picard, Benjamin [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program]
	Munch, Marion [Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Department of Diabetology, Médicale B]
	Lefebvre, François [Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Department of Methodology and Biostatistics]
	Baltzinger, Philippe [Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Department of Diabetology, Médicale B]
	Porzio, Michele [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program]
	Hirschi, Sandrine [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program]
	Dégot, Tristan [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Division of Respiratology and Strasbourg Lung Transplant Program]
	Schuller, Armelle [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Division of Respiratology and Strasbourg Lung Transplant Program]
	Santelmo, Nicola [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program]
	Reeb, Jeremie [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program]
	Olland, Anne [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program]
	Falcoz, Pierre-Emmanuel [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program]
	Massard, Gilbert [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > > ; Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program]
	Kessler, Laurence [Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Department of Diabetology, Médicale B]
	Kessler, Romain [Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program]
Publication date :	Dec-2019
Journal title :	Transplantation Proceedings
Publisher :	Appleton & Lange
Peer reviewed :	Yes (verified by ORBilu)
Audience :	International
ISSN :	0041-1345
e-ISSN :	1873-2623
City :	New York
Country :	NY
Abstract :	[en] Objective: To study patient survival and glycemic control before and after lung transplantation (LTx) according to the diabetes status in patients submitted to an organized management of diabetes mellitus (DM) at the Strasbourg University Hospital, France. Material and methods: Two hundred and sixty-seven LTx recipients were included retrospectively and analyzed according to diabetes status: pretransplant diabetes, new-onset diabetes mellitus after transplant (NODAT) or no diabetes. Organized DM management was coordinated by a diabetologist trained in DM management before and after transplantation and included pretransplant screening, a close monitoring of glycemia after transplant and optimized treatment before and after LTx. Results: DM was well-controlled after transplantation: mean glycosylated hemoglobin and fasting blood glucose levels after LTx were 5.8 ± 0.2% and 5.4 ± 0.1 mmol/L respectively, in pretransplant DM patients and 5.7 ± 0.1% and 5.6 ± 0.2 mmol/L respectively, in NODAT patients. The overall median survival time was 8.3 ± 1.9 years. Pretransplant DM increased the risk of mortality (1.82-fold increase; 95% confidence interval, 1.08-3.06; P = .02) in LTx recipients. Conclusions: Organized management of diabetes achieved very satisfactory glycemic control in both pretransplant DM and NODAT patients. However, no specific protocols have been created for managing DM following LTx. As DM continues to become an increasing comorbidity in LTx, there exist a significant need of studies in this area.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/10993/42782
DOI :	10.1016/j.transproceed.2019.07.019

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