Article (Scientific journals)
Organized Management of Diabetes Mellitus in Lung Transplantation: Study of Glycemic Control and Patient Survival in a Single Center
Riou, Marianne; Renaud-Picard, Benjamin; Munch, Marion et al.
2019In Transplantation Proceedings
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Abstract :
[en] Objective: To study patient survival and glycemic control before and after lung transplantation (LTx) according to the diabetes status in patients submitted to an organized management of diabetes mellitus (DM) at the Strasbourg University Hospital, France. Material and methods: Two hundred and sixty-seven LTx recipients were included retrospectively and analyzed according to diabetes status: pretransplant diabetes, new-onset diabetes mellitus after transplant (NODAT) or no diabetes. Organized DM management was coordinated by a diabetologist trained in DM management before and after transplantation and included pretransplant screening, a close monitoring of glycemia after transplant and optimized treatment before and after LTx. Results: DM was well-controlled after transplantation: mean glycosylated hemoglobin and fasting blood glucose levels after LTx were 5.8 ± 0.2% and 5.4 ± 0.1 mmol/L respectively, in pretransplant DM patients and 5.7 ± 0.1% and 5.6 ± 0.2 mmol/L respectively, in NODAT patients. The overall median survival time was 8.3 ± 1.9 years. Pretransplant DM increased the risk of mortality (1.82-fold increase; 95% confidence interval, 1.08-3.06; P = .02) in LTx recipients. Conclusions: Organized management of diabetes achieved very satisfactory glycemic control in both pretransplant DM and NODAT patients. However, no specific protocols have been created for managing DM following LTx. As DM continues to become an increasing comorbidity in LTx, there exist a significant need of studies in this area.
Disciplines :
Surgery
Author, co-author :
Riou, Marianne;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program,
Renaud-Picard, Benjamin;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program
Munch, Marion;  Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Department of Diabetology, Médicale B
Lefebvre, François;  Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Department of Methodology and Biostatistics
Baltzinger, Philippe;  Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Department of Diabetology, Médicale B
Porzio, Michele;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program
Hirschi, Sandrine;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program
Dégot, Tristan;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Division of Respiratology and Strasbourg Lung Transplant Program
Schuller, Armelle;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. > Division of Respiratology and Strasbourg Lung Transplant Program
Santelmo, Nicola;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program
Reeb, Jeremie;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program
Olland, Anne;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program
Falcoz, Pierre-Emmanuel;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program
Massard, Gilbert ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) ; Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Thoracic Surgery and Strasbourg Lung Transplant Program
Kessler, Laurence;  Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Department of Diabetology, Médicale B
Kessler, Romain;  Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France > Division of Respiratology and Strasbourg Lung Transplant Program
More authors (6 more) Less
External co-authors :
yes
Language :
English
Title :
Organized Management of Diabetes Mellitus in Lung Transplantation: Study of Glycemic Control and Patient Survival in a Single Center
Publication date :
December 2019
Journal title :
Transplantation Proceedings
ISSN :
1873-2623
Publisher :
Appleton & Lange, New York, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 10 March 2020

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