Article (Scientific journals)
Quality of life predicts outcome of deep brain stimulation in early Parkinson disease
Krüger, Rejko; EARLYSTIM study group; Schuepbach, Michael et al.
2019In Neurology
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Keywords :
Quality of Life; Deep Brain Stimulation; Parkinson's disease
Abstract :
[en] Objective Toinvestigatepredictorsforimprovementofdisease-specificqualityoflife(QOL)afterdeepbrainstimulation (DBS) of the subthalamic nucleus (STN) for Parkinson disease (PD) with early motor complications. Methods We performed a secondary analysis of data from the previously published EARLYSTIM study, a prospective randomizedtrialcomparingSTN-DBS(n= 124)tobestmedicaltreatment(n= 127)after2yearsfollow-up with disease-specific QOL (39-item Parkinson ’s Disease Questionnaire summary index [PDQ-39-SI]) as the primary endpoint. Linear regression analyses of the baseline characteristics age, disease duration, duration of motor complications, and disease severity measured at baseline with the Unified Parkinson’s Disease Rating Scale(UPDRS)(UPDRS-III“off”and“on”medications,UPDRS-IV)wereconductedtodeterminepredictors of change in PDQ-39-SI. Results PDQ-39-SIatbaselinewascorrelatedtothechangeinPDQ-39-SIafter24monthsinbothtreatmentgroups (p<0.05).Thehigherthebaselinescore(worseQOL)thelargertheimprovementinQOLafter24months. No correlation was found for any of the other baseline characteristics analyzed in either treatment group. Conclusion Impaired QOL as subjectively evaluated by the patient is the most important predictor of benefit in patients with PD and early motor complications, fulfilling objective gold standard inclusion criteria for STN-DBS. Our results prompt systematically including evaluation of disease-specific QOL when selecting patients with PD for STN-DBS.
Disciplines :
Author, co-author :
Krüger, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
EARLYSTIM study group
Schuepbach, Michael;  Département de Neurologie > Hôpital Pitié-Salpêtrière
Deuschl, Gunther;  Universitätsklinikum Giessen und Marburg (L.T.)
External co-authors :
Language :
Title :
Quality of life predicts outcome of deep brain stimulation in early Parkinson disease
Publication date :
05 March 2019
Journal title :
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
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since 22 January 2020


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