Rauschenberger, Armin[University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; Amsterdam UMC, VU University Amsterdam, Amsterdam, The Netherlands]
[en] prediction ; sparsity ; lasso regression ; paired data
[en] This paper introduces the paired lasso: a generalisation of the lasso for paired covariate settings. Our aim is to predict a single response from two high-dimensional covariate sets. We assume a one-to-one correspondence between the covariate sets, with each covariate in one set forming a pair with a covariate in the other set. Paired covariates arise, for example, when two transformations of the same data are available. It is often unknown which of the two covariate sets leads to better predictions, or whether the two covariate sets complement each other. The paired lasso addresses this problem by weighting the covariates to improve the selection from the covariate sets and the covariate pairs. It thereby combines information from both covariate sets and accounts for the paired structure. We tested the paired lasso on more than 2000 classification problems with experimental genomics data, and found that for estimating sparse but predictive models, the paired lasso outperforms the standard and the adaptive lasso. The R package palasso is available from CRAN.
Amsterdam UMC, VU University Amsterdam, Department of Epidemiology and Biostatistics ; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
[University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; Amsterdam UMC, VU University Amsterdam, Amsterdam, The Netherlands]
