Article (Scientific journals)
Kinetic Control of Parallel versus Antiparallel Amyloid Aggregation via Shape of the Growing Aggregate
Hakami Zanjani, Ali Asghar; Reynolds, Nicholas; Zhang, Afang et al.
2019In Nature Scientific Reports
Peer reviewed
 

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Keywords :
amyloid; kinetics; lysozyme
Abstract :
[en] By combining atomistic and higher-level modelling with solution X-ray diffraction we analyse self-assembly pathways for the IFQINS hexapeptide, a bio-relevant amyloid former derived from human lysozyme. We verify that (at least) two metastable polymorphic structures exist for this system which are substantially different at the atomistic scale, and compare the conditions under which they are kinetically accessible. We further examine the higher-level polymorphism for these systems at the nanometre to micrometre scales, which is manifested in kinetic differences and in shape differences between structures instead of or as well as differences in the small-scale contact topology. Any future design of structure based inhibitors of the IFQINS steric zipper, or of close homologues such as TFQINS which are likely to have similar structures, should take account of this polymorphic assembly.
Research center :
ULHPC - University of Luxembourg: High Performance Computing
Disciplines :
Physics
Author, co-author :
Hakami Zanjani, Ali Asghar ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
Reynolds, Nicholas;  Swinburne University of Technology > ARC Training Centre for Biodevices
Zhang, Afang;  Shanghai University > Department of Polymer Materials
Schilling, Tanja ;  University of Freiburg > Physics
Mezzenga, Raffaele;  ETH Zurich > Department of Health Sciences and Technology ; ETH Zurich > Department of Materials
Berryman, Josh  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
External co-authors :
yes
Language :
English
Title :
Kinetic Control of Parallel versus Antiparallel Amyloid Aggregation via Shape of the Growing Aggregate
Publication date :
05 November 2019
Journal title :
Nature Scientific Reports
ISSN :
2045-2322
Peer reviewed :
Peer reviewed
Focus Area :
Physics and Materials Science
FnR Project :
FNR8329720 - Assembly Kinetics And Phase Diagram Of A Lysozyme-derived Peptide, 2014 (01/09/2015-31/08/2018) - Joshua T Berryman
Name of the research project :
Assembly Kinetics and Phase Diagram of a Lysozyme-Derived Peptide
Funders :
FNR - Fonds National de la Recherche [LU]
ARC - Australian Research Council [AU]
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