Reference : Kinetic Control of Parallel versus Antiparallel Amyloid Aggregation via Shape of the ...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
Physics and Materials Science
http://hdl.handle.net/10993/41202
Kinetic Control of Parallel versus Antiparallel Amyloid Aggregation via Shape of the Growing Aggregate
English
Hakami Zanjani, Ali Asghar mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
Reynolds, Nicholas mailto [Swinburne University of Technology > ARC Training Centre for Biodevices]
Zhang, Afang mailto [Shanghai University > Department of Polymer Materials]
Schilling, Tanja mailto [University of Freiburg > Physics]
Mezzenga, Raffaele mailto [ETH Zurich > Department of Health Sciences and Technology > > ; ETH Zurich > Department of Materials]
Berryman, Josh mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
5-Nov-2019
Nature Scientific Reports
Yes (verified by ORBilu)
International
2045-2322
[en] amyloid ; kinetics ; lysozyme
[en] By combining atomistic and higher-level modelling with solution X-ray diffraction we analyse self-assembly pathways for the IFQINS hexapeptide, a bio-relevant amyloid former derived from human lysozyme. We verify that (at least) two metastable polymorphic structures exist for this system which are substantially different at the atomistic scale, and compare the conditions under which they are kinetically accessible. We further examine the higher-level polymorphism for these systems at the nanometre to micrometre scales, which is manifested in kinetic differences and in shape differences between structures instead of or as well as differences in the small-scale contact topology. Any future design of structure based inhibitors of the IFQINS steric zipper, or of close homologues such as TFQINS which are likely to have similar structures, should take account of this polymorphic assembly.
University of Luxembourg: High Performance Computing - ULHPC
Fonds National de la Recherche - FnR ; Australian Research Council (ARC)
Assembly Kinetics and Phase Diagram of a Lysozyme-Derived Peptide
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/41202
10.1038/s41598-019-52238-x
https://www.nature.com/articles/s41598-019-52238-x
FnR ; FNR8329720 > Joshua T Berryman > ILQINS > ASSEMBLY KINETICS AND PHASE DIAGRAM OF A LYSOZYME-DERIVED PEPTIDE > 01/09/2015 > 31/08/2018 > 2014

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