Article (Scientific journals)
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells
Ullmann, Pit; Nurmik, Martin; Begaj, Rubens et al.
2019In Cells, 8 (6)
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Keywords :
cancer stem cell; colorectal cancer; hypoxia; metabolic reprogramming; miR-210; stemness; tumor-initiating cell
Abstract :
[en] Colorectal cancer (CRC), the second most common cause of cancer mortality in theWestern world, is a highly heterogeneous disease that is driven by a rare subpopulation of tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Over the past few years, a plethora of di erent approaches, aimed at identifying and eradicating these self-renewing TICs, have been described. A focus on the metabolic and bioenergetic di erences between TICs and less aggressive di erentiated cancer cells has thereby emerged as a promising strategy to specifically target the tumorigenic cell compartment. Extrinsic factors, such as nutrient availability or tumor hypoxia, are known to influence the metabolic state of TICs. In this review, we aim to summarize the current knowledge on environmental stress factors and how they a ect the metabolism of TICs, with a special focus on microRNA (miRNA)- and hypoxia-induced e ects on colon TICs.
Research center :
University of Luxembourg
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Ullmann, Pit;  Life Sciences Research Unit, University of Luxembourg > Molecular Disease Mechanisms Group
Nurmik, Martin ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Begaj, Rubens  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Haan, Serge ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Letellier, Elisabeth ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
no
Language :
English
Title :
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells
Publication date :
01 June 2019
Journal title :
Cells
ISSN :
2073-4409
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Basel, Switzerland
Volume :
8
Issue :
6
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
FnR Project :
FNR7855578 - Identification And Functional Investigation Of Hypoxia-induced Mirnas In Colon Cancer Stem Cells, 2014 (01/03/2014-31/05/2017) - Pit Ullmann
Funders :
Fondation Cancer
Fondation du Pélican de Mie
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since 07 October 2019

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