Reference : Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/40624

Title :	Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells
Language :	English
Author, co-author :	Ullmann, Pit [Life Sciences Research Unit, University of Luxembourg > Molecular Disease Mechanisms Group]
	Nurmik, Martin [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Begaj, Rubens [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Haan, Serge [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Letellier, Elisabeth [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Publication date :	1-Jun-2019
Journal title :	Cells
Publisher :	Multidisciplinary Digital Publishing Institute (MDPI)
Volume :	8
Issue/season :	6
Peer reviewed :	Yes
Audience :	International
e-ISSN :	2073-4409
City :	Basel
Country :	Switzerland
Keywords :	[lb] cancer stem cell ; colorectal cancer ; hypoxia
	[en] metabolic reprogramming ; miR-210 ; stemness ; tumor-initiating cell
Abstract :	[en] Colorectal cancer (CRC), the second most common cause of cancer mortality in theWestern world, is a highly heterogeneous disease that is driven by a rare subpopulation of tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Over the past few years, a plethora of di erent approaches, aimed at identifying and eradicating these self-renewing TICs, have been described. A focus on the metabolic and bioenergetic di erences between TICs and less aggressive di erentiated cancer cells has thereby emerged as a promising strategy to specifically target the tumorigenic cell compartment. Extrinsic factors, such as nutrient availability or tumor hypoxia, are known to influence the metabolic state of TICs. In this review, we aim to summarize the current knowledge on environmental stress factors and how they a ect the metabolism of TICs, with a special focus on microRNA (miRNA)- and hypoxia-induced e ects on colon TICs.
Research centres :	University of Luxembourg
Funders :	Fondation Cancer ; Fondation du Pélican de Mie
Target :	Researchers ; Others
Permalink :	http://hdl.handle.net/10993/40624
DOI :	10.3390/cells8060528
FnR project :	FnR ; FNR7855578 > Pit Ullmann > > Identification and functional investigation of hypoxia-induced miRNAs in colon cancer stem cells > 01/03/2014 > 31/05/2017 > 2014

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Open access Hypoxia- and MicroRNA-Induced.pdf Publisher postprint 996.71 kB View/Open

All documents in ORBi^lu are protected by a user license.

 

University of Luxembourg Library |  Feedback |  Legal notices Site Map