Reference : Mitochondrial morphology provides a mechanism for energy buffering at synapses
E-prints/Working papers : Already available on another site
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/39715
Mitochondrial morphology provides a mechanism for energy buffering at synapses
English
Garcia, Guadalupe Clara mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Bartol, Thomas M. [Salk Institute for Biological Studies]
Phan, Sebastien A. [National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.]
Bushong, Eric A. [National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.]
Perkins, Guy [National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.]
Sejnowski, Terrence J. [Salk Institute for Biological Studies]
Ellisman, Mark H. [National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
20-May-2019
No
[en] mitochondria ; morphology ; reaction-diffusion systems ; agent-based modeling
[en] Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these processes are well established, substantial evidence indicates that the internal structure is also highly variable in dependence on metabolic conditions. However, a quantitative mechanistic understanding of how mitochondrial morphology affects energetic states is still elusive. To address this question, we here present an agent-based dynamic model using three-dimensional morphologies from electron microscopy tomography which considers the molecular dynamics of the main ATP production components. We apply our modeling approach to mitochondria at the synapse which is the largest energy consumer within the brain. Interestingly, comparing the spatiotemporal simulations with a corresponding space-independent approach, we find minor space dependence when the system relaxes toward equilibrium but a qualitative difference in fluctuating environments. These results suggest that internal mitochondrial morphology is not only optimized for ATP production but also provides a mechanism for energy buffering and may represent a mechanism for cellular robustness.
http://hdl.handle.net/10993/39715
10.1101/643551
https://www.biorxiv.org/content/10.1101/643551v1
FnR ; FNR9984574 > Guadalupe Clara Garcia > > A realistic model of the mitochondrion > 01/05/2015 > 30/04/2019 > 2015

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