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Mitochondrial morphology provides a mechanism for energy buffering at synapses
Garcia, Guadalupe Clara; Bartol, Thomas M.; Phan, Sebastien A. et al.
2019
 

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Keywords :
mitochondria; morphology; reaction-diffusion systems; agent-based modeling
Abstract :
[en] Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these processes are well established, substantial evidence indicates that the internal structure is also highly variable in dependence on metabolic conditions. However, a quantitative mechanistic understanding of how mitochondrial morphology affects energetic states is still elusive. To address this question, we here present an agent-based dynamic model using three-dimensional morphologies from electron microscopy tomography which considers the molecular dynamics of the main ATP production components. We apply our modeling approach to mitochondria at the synapse which is the largest energy consumer within the brain. Interestingly, comparing the spatiotemporal simulations with a corresponding space-independent approach, we find minor space dependence when the system relaxes toward equilibrium but a qualitative difference in fluctuating environments. These results suggest that internal mitochondrial morphology is not only optimized for ATP production but also provides a mechanism for energy buffering and may represent a mechanism for cellular robustness.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Garcia, Guadalupe Clara ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Bartol, Thomas M.;  Salk Institute for Biological Studies
Phan, Sebastien A.;  National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.
Bushong, Eric A.;  National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.
Perkins, Guy;  National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.
Sejnowski, Terrence J.;  Salk Institute for Biological Studies
Ellisman, Mark H.;  National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego.
Skupin, Alexander  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Language :
English
Title :
Mitochondrial morphology provides a mechanism for energy buffering at synapses
Publication date :
20 May 2019
FnR Project :
FNR9984574 - A Realistic Model Of The Mitochondrion, 2015 (01/05/2015-22/09/2019) - Guadalupe Clara Garcia
Available on ORBilu :
since 21 June 2019

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