[en] Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.
Disciplines :
Chimie
Auteur, co-auteur :
THINNES, Cyrille ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Lohans, Christopher T.
Abboud, Martine I.
Yeh, Tzu-Lan
Tumber, Anthony
Nowak, Radoslaw P.
Attwood, Martin
Cockman, Matthew E.
Oppermann, Udo
Loenarz, Christoph
Schofield, Christopher J.
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.
Date de publication/diffusion :
2019
Titre du périodique :
Chemistry
ISSN :
0947-6539
eISSN :
1521-3765
Maison d'édition :
John Wiley & Sons, Allemagne
Volume/Tome :
25
Fascicule/Saison :
8
Pagination :
2019-2024
Peer reviewed :
Peer reviewed vérifié par ORBi
Commentaire :
(c) 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
