Reference : Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Dec...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.
Thinnes, Cyrille mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Lohans, Christopher T. [> >]
Abboud, Martine I. [> >]
Yeh, Tzu-Lan [> >]
Tumber, Anthony [> >]
Nowak, Radoslaw P. [> >]
Attwood, Martin [> >]
Cockman, Matthew E. [> >]
Oppermann, Udo [> >]
Loenarz, Christoph [> >]
Schofield, Christopher J. [> >]
Chemistry (Weinheim an der Bergstrasse, Germany)
Yes (verified by ORBilu)
[en] 2-oxoglutarate oxygenase ; OGFOD1 ; barbiturate ; epigenetics ; histone demethylases ; inhibitors ; medicinal chemistry
[en] Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.
(c) 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

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