Reference : Sympathetic activity relates to adenosine A2A receptor gene variation in blood-injury...
Scientific journals : Article
Social & behavioral sciences, psychology : Animal psychology, ethology & psychobiology
Social & behavioral sciences, psychology : Neurosciences & behavior
Social & behavioral sciences, psychology : Theoretical & cognitive psychology
Social & behavioral sciences, psychology : Treatment & clinical psychology
Human health sciences : Psychiatry
Sympathetic activity relates to adenosine A2A receptor gene variation in blood-injury phobia
Hohoff, Christa [> >]
Domschke, Katharina [> >]
Schwarte, Kathrin [> >]
Spellmeyer, Gerd [> >]
Vögele, Claus mailto [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE) >]
Hetzel, Günther [> >]
Deckert, Jürgen [> >]
Gerlach, Alexander L. [> >]
Journal of Neural Transmission
Springer Verlag
Yes (verified by ORBilu)
[en] Anxiety ; Blood pressure ; Respiration rate ; Minute volume ; ADORA2A ; Polymorphism
[en] Variation in the candidate genes adenosine A(2A) receptor (A(2A)R), catechol-O-methyl-transferase (COMT), and norepinephrine transporter (NET) has been suggested to influence vulnerability to panic disorder. We therefore investigated patients with another anxiety disorder with an even higher heritability, the blood-injury phobia, for association of these variants and used sympathetic measures during venipuncture, which serve as a naturalistic trigger of anxiety and autonomic hyperarousal, as an intermediate phenotype of anxiety. Patients homozygous for the A(2A)R 1976T allele as compared to patients carrying at least one 1976C allele exhibited a significantly increased respiratory rate with a trend towards elevated measures of systolic and diastolic blood pressure and respiratory minute volume. None of the sympathetic measures were influenced by the COMT or NET polymorphisms.This study provides preliminary data suggesting an influence of the A(2A)R 1976C/T polymorphism on sympathetic psychophysiological indicators of anxiety-related arousal in blood-injury phobia and thereby further supports a role of the A(2A)R gene in the pathogenesis of anxiety disorders.
Researchers ; Students

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