Cloud-Assisted Read Alignment and Privacy

FERNANDES, Maria; DECOUCHANT, Jérémie; Couto, Francisco M.; VERISSIMO, Paulo

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Cloud-Assisted Read Alignment and Privacy

FERNANDES, Maria; DECOUCHANT, Jérémie; Couto, Francisco M. et al.

2017 • In 11th International Conference on Practical Applications of Computational Biology & Bioinformatics 2017

Peer reviewed

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https://hdl.handle.net/10993/34971

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Keywords :

Read alignment; Cloud computing; Genomic data privacy

Abstract :

[en] Thanks to the rapid advances in sequencing technologies, genomic data is now being produced at an unprecedented rate. To adapt to this growth, several algorithms and paradigm shifts have been proposed to increase the throughput of the classical DNA workflow, e.g. by relying on the cloud to perform CPU intensive operations. However, the scientific community raised an alarm due to the possible privacy-related attacks that can be executed on genomic data. In this paper we review the state of the art in cloud-based alignment algorithms that have been developed for performance. We then present several privacy-preserving mechanisms that have been, or could be, used to align reads at an incremental performance cost. We finally argue for the use of risk analysis throughout the DNA workflow, to strike a balance between performance and protection of data.

Research center :

Interdisciplinary Centre for Security, Reliability and Trust (SnT) > Critical and Extreme Security and Dependability Research Group (CritiX)

Disciplines :

Computer science

Author, co-author :

FERNANDES, Maria ; University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT)

DECOUCHANT, Jérémie ; University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT)

Couto, Francisco M.; LaSIGE, Faculdade de Ciencias, Universidade de Lisboa, Portugal

VERISSIMO, Paulo ; University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT)

External co-authors :

yes

Language :

English

Title :

Cloud-Assisted Read Alignment and Privacy

Publication date :

2017

Event name :

11th International Conference on Practical Applications of Computational Biology & Bioinformatics 2017

Event date :

from 21-06-2017 to 23-06-2018

Audience :

International

Main work title :

11th International Conference on Practical Applications of Computational Biology & Bioinformatics 2017

Peer reviewed :

Peer reviewed

Focus Area :

Security, Reliability and Trust

Funders :

FNR - Fonds National de la Recherche

Available on ORBilu :

since 22 February 2018

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