Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress

Li-Tempel, T.; Larra, M. F.; Winnikes, U.; Tempel, T.; de Rijk, R. H.; Schulz, André; Schächinger, H.; Meyer, J.; Schote, A. B.

Reference : Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence t...


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/10993/27970

Title :	Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress
Language :	English
Author, co-author :	Li-Tempel, T. []
	Larra, M. F. []
	Winnikes, U. []
	Tempel, T. []
	de Rijk, R. H. []
	Schulz, André [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE) >]
	Schächinger, H. []
	Meyer, J. []
	Schote, A. B. []
Publication date :	Sep-2016
Journal title :	Biological Psychology
Publisher :	Elsevier Science
Volume :	119
Issue/season :	1
Pages :	112-121
Peer reviewed :	Yes (verified by ORBi^lu)
Audience :	International
ISSN :	0301-0511
City :	Amsterdam
Country :	The Netherlands
Abstract :	[en] The hypothalamus-pituitary-adrenal (HPA) axis is a crucial endocrine system for coping with stress. A reliable and stable marker for the basal state of that system is the cortisol awakening response (CAR). We examined the influence of variants of four relevant candidate genes; the mineralocorticoid receptor gene (MR), the glucocorticoid receptor gene (GR), the serotonin transporter gene (5-HTT) and the gene encoding the brain-derived neurotrophic factor (BDNF) on CAR and self-perceived stress in 217 healthy subjects. We found that polymorphisms of GR influenced both, the basal state of the HPA axis as well as self-perceived stress. MR only associated with self-perceived stress and 5-HTT only with CAR. BDNF did not affected any of the investigated indices. In summary, we suggest that GR variants together with the CAR and supplemented with self reports on perceived stress might be useful indicators for the basal HPA axis activity.
Permalink :	http://hdl.handle.net/10993/27970

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