Cardiac metabolism; from bench to bedside: Diabetic  cardiomyopathy, a disease of cardiac metabolism?

Diabetes Mellitus/drug therapy/pathology; Diabetic Cardiomyopathies/drug therapy/etiology/metabolism; Disease Progression; Fatty Acids, Nonesterified/metabolism; Humans; Inflammation; Lipid Metabolism; Male; Middle Aged; Mitochondria/metabolism/pathology; Myocardial Infarction/etiology; Myocardium/metabolism/pathology; Oxidative Stress; Prognosis; Risk Factors

Abstract :

[en] The study of diabetic cardiomyopathy is an area of significant interest given the strong association between diabetes and the risk of heart failure. Many unanswered questions remain regarding the clinical definition and pathogenesis of this metabolic cardiomyopathy. This article reviews the current understanding of diabetic cardiomyopathy with a particular emphasis on the unresolved issues that have limited translation of scientific discovery to patient bedside.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Neyses, Ludwig ; University of Luxembourg > Rectorate > Research Service

External co-authors :