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Article (Scientific journals)
The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease.
Oceandy, Delvac; Buch, Mamta H.; Cartwright, Elizabeth J. et al.
2006In Mini Reviews in Medicinal Chemistry, 6 (5), p. 583-8
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Keywords :
Calcium-Transporting ATPases/antagonists & inhibitors/chemistry/drug effects; Cation Transport Proteins/antagonists & inhibitors/chemistry/drug effects; Cell Division; Enzyme Inhibitors/pharmacology; Heart Diseases/drug therapy/metabolism; Humans; Plasma Membrane Calcium-Transporting ATPases; Signal Transduction; Subcellular Fractions/enzymology
Abstract :
[en] The plasma membrane calcium/calmodulin dependent ATPase (PMCA) is a calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. PMCA is the only system for calcium extrusion in the majority of cells. In excitable cells such as cardiomyocytes however, PMCA has been shown to play only a minor role in calcium homeostasis. In these cells the main mechanism of calcium extrusion is the sodium calcium exchanger. However, increasing evidence points to an important role for PMCA in signal transduction; in particular in the nitric oxide signalling pathway. In this review we will discuss recent advances that support a key role for PMCA in signal transduction and the potential for therapeutic targeting of this molecule in the treatment of cardiac diseases.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Oceandy, Delvac
Buch, Mamta H.
Cartwright, Elizabeth J.
Neyses, Ludwig ;  University of Luxembourg > Research Office
External co-authors :
yes
Language :
English
Title :
The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease.
Publication date :
2006
Journal title :
Mini Reviews in Medicinal Chemistry
ISSN :
1389-5575
Publisher :
Bentham Science Publishers, United Arab Emirates
Volume :
6
Issue :
5
Pages :
583-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 01 June 2016

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