Article (Scientific journals)
Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: A histochemical and immunohistochemical study
Deftereou, Theodora-Eleftheria; Lambropoulou, Maria; Chatzaki, Ekaterini et al.
2012In Folia Histochemica et Cytobiologica, 50 (1), p. 118-124
Peer reviewed
 

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Keywords :
Apoptosis; Chorioamnionitis; Congenital disorders; Immunohistochemistry; Placenta; Abortion, Spontaneous; Female; Humans; Inflammation; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second
Abstract :
[en] The aim of this study was to investigate the role of apoptotic markers on inflammatory human placentas from spontaneous abortions during the first and second trimester of gestation and compare them to those without inflammation. Paraffin-embedded specimens from 76 placentas were investigated by conventional histology and immunohistochemistry using monoclonal antibodies against M30, Caspase 3, Caspase 8 and Caspase 9, as well as the terminal deoxynucleotidyl tranferase-mediated deoxyuridine triphosphate nick end labeling method. A higher prevalence of expression of apoptotic markers (94.4%) was observed in placentas associated with chorioamnionitis in comparison with those without inflammation. Our observations confirm that apoptosis is strikingly prevalent in placentas diagnosed with histologic chorioamnionitis, while the inflammation induces cell death. © Polish Society for Histochemistry and Cytochemistry.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
eid=2-s2.0-84860303143
Author, co-author :
Deftereou, Theodora-Eleftheria;  Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
Lambropoulou, Maria;  Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
Chatzaki, Ekaterini;  Laboratory of Pharmacology, Democritus University of Thrace, Greece
Koffa, Maria ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Ypsilantis, Petros;  Laboratory of Experimental Surgery and Surgical Research, Democritus University of Thrace, Greece
Pagonopoulou, Olga;  Laboratory of Physiology, Democritus University of Thrace, Greece
Grammatikopoulou, Iordana;  Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
Papadopoulos, Elias;  Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
Papalambros, Alexandros;  Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
Kontomanolis, Emmanouil;  Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece
Papadopoulos, Nikolas;  Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
External co-authors :
yes
Language :
English
Title :
Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: A histochemical and immunohistochemical study
Publication date :
2012
Journal title :
Folia Histochemica et Cytobiologica
ISSN :
0239-8508
Volume :
50
Issue :
1
Pages :
118-124
Peer reviewed :
Peer reviewed
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