Reference : Increased apoptotic activity on inflammatory human placentas in spontaneous abortions...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/10993/27430

Title :	Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: A histochemical and immunohistochemical study
Language :	English
Author, co-author :	Deftereou, Theodora-Eleftheria [Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece]
	Lambropoulou, Maria [Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece]
	Chatzaki, Ekaterini [Laboratory of Pharmacology, Democritus University of Thrace, Greece]
	Koffa, Maria [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
	Ypsilantis, Petros [Laboratory of Experimental Surgery and Surgical Research, Democritus University of Thrace, Greece]
	Pagonopoulou, Olga [Laboratory of Physiology, Democritus University of Thrace, Greece]
	Grammatikopoulou, Iordana [Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece]
	Papadopoulos, Elias [Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece]
	Papalambros, Alexandros [Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece]
	Kontomanolis, Emmanouil [Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece]
	Papadopoulos, Nikolas [Laboratory of Histology-Embryology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece]
Publication date :	2012
Journal title :	Folia Histochemica et Cytobiologica
Volume :	50
Issue/season :	1
Pages :	118-124
Peer reviewed :	Yes
Audience :	International
ISSN :	02398508
Keywords :	[en] Apoptosis ; Chorioamnionitis ; Congenital disorders ; Immunohistochemistry ; Placenta ; Abortion, Spontaneous ; Female ; Humans ; Inflammation ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second
Abstract :	[en] The aim of this study was to investigate the role of apoptotic markers on inflammatory human placentas from spontaneous abortions during the first and second trimester of gestation and compare them to those without inflammation. Paraffin-embedded specimens from 76 placentas were investigated by conventional histology and immunohistochemistry using monoclonal antibodies against M30, Caspase 3, Caspase 8 and Caspase 9, as well as the terminal deoxynucleotidyl tranferase-mediated deoxyuridine triphosphate nick end labeling method. A higher prevalence of expression of apoptotic markers (94.4%) was observed in placentas associated with chorioamnionitis in comparison with those without inflammation. Our observations confirm that apoptosis is strikingly prevalent in placentas diagnosed with histologic chorioamnionitis, while the inflammation induces cell death. © Polish Society for Histochemistry and Cytochemistry.
Permalink :	http://hdl.handle.net/10993/27430
DOI :	10.5603/FHC.2012.0017

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