Article (Scientific journals)
Paediatric screening for hypercholesterolaemia in Europe
Kusters, D.M.; De Beaufort, Carine; Widhalm, K. et al.
2011In Archives of Disease in Childhood, 97 (3), p. 272-276
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Keywords :
screening strategies; familial hypercholesterolaemia; identification; children; genetics; early lipid management; Europe; selective screening strategies; effectiveness
Abstract :
[en] Different screening strategies are currently recommended to identify children with (familial) hypercholesterolaemia in order to initiate early lipid management. However, these strategies are characterised to date by low adherence by the medical community and limited compliance by parents and children. In a literature review, the authors assess which children should undergo screening and which children are in effect identified through the currently recommended strategies. Furthermore, the authors discuss the different screening tools and strategies currently used in Europe and what is known about the negative aspects of screening. The authors conclude that currently recommended selective screening strategies, which are mainly based on family history, lack precision and that a large percentage of affected children who are at increased risk of future coronary artery disease are not being identified. The authors propose universal screening of children between 1 and 9 years of age, a strategy likely to be most effective in terms of sensitivity and specificity for the identification of children with familial hypercholesterolaemia. However, this concept has yet to be proven in clinical practice.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Kusters, D.M.
De Beaufort, Carine ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Widhalm, K.
Guardamagna, O.
Bratina, N.
Ose, L.
Wiegman, A.
External co-authors :
yes
Language :
English
Title :
Paediatric screening for hypercholesterolaemia in Europe
Publication date :
26 September 2011
Journal title :
Archives of Disease in Childhood
ISSN :
1468-2044
Publisher :
British Medical Association, London, United Kingdom
Volume :
97
Issue :
3
Pages :
272-276
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 20 May 2016

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