Reference : Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptid...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/27352

Title :	Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes
Language :	English
Author, co-author :	Pfleger, C. []
	Kaas, A. []
	Hansen, L. []
	Alizadeh, B. []
	Hougaard, P. []
	Holl, R. []
	Holb, H. []
	Roep, B.O. []
	Mortensen, H.B. []
	Schloot, N.C. []
Other contributor :	De Beaufort, Carine [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Publication date :	Jul-2008
Journal title :	Clinical Immunology
Publisher :	Academic Press
Volume :	128
Issue/season :	1
Pages :	57-65
Peer reviewed :	Yes (verified by ORBilu)
ISSN :	1521-6616
e-ISSN :	1521-7035
City :	San Diego
Country :	CA
Keywords :	[en] chemokines ; Ccl3/Mip-1alpha ; Ccl5/Rantes ; Ccl4/Mip-1beta ; Th2 ; type 1 diabetes mellitus ; proinsulin ; c-peptide ; inflammation ; disease progression ; remission ; children
Abstract :	[en] Th1 related chemokines CCL3 and CCL5 and Th2 related CCL4 as ligands of the receptor CCR5 contribute to disease development in animal models of type 1 diabetes. In humans, no data are available addressing the role of these chemokines regarding disease progression and remission. We investigated longitudinally circulating concentrations of CCR5 ligands of 256 newly diagnosed patients with type 1 diabetes. CCR5 ligands were differentially associated with beta-cell function and clinical remission. CCL5 was decreased in remitters and positively associated with HbA1c suggestive of a Th1 associated progression of the disease. Likewise, CCL3 was negatively related to C-peptide and positively associated with the beta-cell stress marker proinsulin but increased in remitters. CCL4 associated with decreased beta-cell stress shown by negative association with proinsulin. Blockage of chemokines or antagonism of CCR5 by therapeutic agents such as maraviroc may provide a new therapeutic target to ameliorate disease progression in type 1 diabetes.
Name of the research project :	Hvidøre Study Group On Childhood Diabetes
Permalink :	http://hdl.handle.net/10993/27352

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