Reference : Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptid...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes
Pfleger, C. []
Kaas, A. []
Hansen, L. []
Alizadeh, B. []
Hougaard, P. []
Holl, R. []
Holb, H. []
Roep, B.O. []
Mortensen, H.B. []
Schloot, N.C. []
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Clinical Immunology
Academic Press
Yes (verified by ORBilu)
San Diego
[en] chemokines ; Ccl3/Mip-1alpha ; Ccl5/Rantes ; Ccl4/Mip-1beta ; Th2 ; type 1 diabetes mellitus ; proinsulin ; c-peptide ; inflammation ; disease progression ; remission ; children
[en] Th1 related chemokines CCL3 and CCL5 and Th2 related CCL4 as ligands of the receptor CCR5 contribute to disease development in animal models of type 1 diabetes. In humans, no data are available addressing the role of these chemokines regarding disease progression and remission. We investigated longitudinally circulating concentrations of CCR5 ligands of 256 newly diagnosed patients with type 1 diabetes. CCR5 ligands were differentially associated with beta-cell function and clinical remission. CCL5 was decreased in remitters and positively associated with HbA1c suggestive of a Th1 associated progression of the disease. Likewise, CCL3 was negatively related to C-peptide and positively associated with the beta-cell stress marker proinsulin but increased in remitters. CCL4 associated with decreased beta-cell stress shown by negative association with proinsulin. Blockage of chemokines or antagonism of CCR5 by therapeutic agents such as maraviroc may provide a new therapeutic target to ameliorate disease progression in type 1 diabetes.
Hvidøre Study Group On Childhood Diabetes

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