Article (Scientific journals)
Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men.
Schiekofer, Stephan; Bobak, Izabela; Kleber, Marcus E. et al.
2014In Diabetes and Vascular Disease Research, 11 (1), p. 60-3
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Keywords :
Aged; Aged, 80 and over; Ataxia Telangiectasia Mutated Proteins/genetics/metabolism; Blood Glucose/analysis; Cohort Studies; Coronary Angiography; Coronary Artery Disease/blood/genetics/metabolism/radiography; Coronary Vessels/radiography; Cross-Sectional Studies; Gene Frequency; Genetic Association Studies; Genetic Loci; Germany; Hospitals, University; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Severity of Illness Index; Statistics as Topic; Vascular disease; co-morbidities; metabolic syndrome
Abstract :
[en] OBJECTIVE: Type 2 diabetes is accompanied by increased mortality from coronary artery disease (CAD), but the mechanisms linking these conditions remain elusive. Hence, treatment of hyperglycaemia alone is not sufficient to avoid CAD in diabetes. Alternative views suggest that metabolic and vascular diseases share unifying cellular defects that could serve as targets for novel therapeutic strategies. Recently, a variant [single-nucleotide polymorphism (SNP); rs11212617] near the gene for ataxia telangiectasia mutated (ATM) has been associated with glycaemic response to metformin. MATERIALS AND METHODS: We determined rs11212617 in 240 male patients who underwent elective coronary angiography. RESULTS: While the variant was not associated with glucose concentrations, the A allele was significantly associated with the presence of CAD (chi-square, p = 0.003), as well as with logarithmically transformed quantitative CAD indices [severe score (SS): 0.5 (0.4-0.6) vs 0.3 (0.2-0.5); extent score (ES): 2.63 (2.4-2.9) vs 1.94 (1.4-2.4), both p < 0.05, respectively]. Multivariate analysis revealed an independent association between the A allele with ES (beta = 0.17, p < 0.01). CONCLUSION: Our data suggest that ATM-dependent signalling might play a role in the development of atherosclerotic vascular disease, but larger studies are necessary to substantiate such a hypothesis.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Medical Translational Research (J. Schneider Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Schiekofer, Stephan
Bobak, Izabela
Kleber, Marcus E.
Maerz, Winfried
Rudofsky, Gottfried
Dugi, Klaus A.
Schneider, Jochen ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men.
Publication date :
2014
Journal title :
Diabetes and Vascular Disease Research
ISSN :
1752-8984
Publisher :
SAGE Publications, New York, United States - New York
Volume :
11
Issue :
1
Pages :
60-3
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 16 May 2016

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