Reference : Inverse association of the endogenous thrombin potential (ETP) with cardiovascular de...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/10993/27267

Title :	Inverse association of the endogenous thrombin potential (ETP) with cardiovascular death: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
Language :	English
Author, co-author :	Schneider, Jochen [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
	Isermann, Berend [> >]
	Kleber, Marcus E. [> >]
	Wang, Hongjie [> >]
	Boehm, Bernhard O. [> >]
	Grammer, Tanja B. [> >]
	Prueller, Florian [> >]
	Nawroth, Peter P. [> >]
	Maerz, Winfried [> >]
Publication date :	2014
Journal title :	International journal of cardiology
Volume :	176
Issue/season :	1
Pages :	139-44
Peer reviewed :	Yes (verified by ORBilu)
ISSN :	0167-5273
e-ISSN :	1874-1754
Country :	Netherlands
Keywords :	[en] Aged ; Biomarkers/blood ; Cardiovascular Diseases/blood/diagnosis/mortality ; Cohort Studies ; Death ; Female ; Follow-Up Studies ; Germany/epidemiology ; Health Status ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Thrombin/metabolism ; Cardiovascular death ; Endogenous thrombin potential ; Thrombin
Abstract :	[en] BACKGROUND: Coagulation and prothrombotic potential have genuinely been associated with increased cardiovascular risk. However, not all studies in this regard are conclusive. Some clinical trials have shown an increased frequency of cardiovascular complications in patients receiving direct thrombin inhibitors. Previous data from human subjects after acute cardiovascular events showed an inverse association between the thrombin generation marker F1+2 and cardiovascular endpoints indicating that not the lowest, but a slightly elevated propensity for thrombin generation is associated with a lower risk of cardiovascular events. This observation has been supported by findings in animal models of atherosclerosis. Hence, we evaluated the association between the endogenous thrombin potential (ETP) and cardiovascular death (CVD) and markers of vascular dysfunction in a large prospective study with long-term follow up. METHOD: After excluding patients receiving anticoagulants we tested ETP in 2196 participants (median follow-up 10 years) for its ability to predict vascular death (CVD). In addition, the association between ETP and sVCAM-1, sICAM-1, LpPLA2, hsCRP and SAA was determined. RESULTS: We observed an inverse association between ETP and CVD with the lowest hazard ratio in the 4th ETP quartile. The nadirs of sICAM-1 or sVCAM-1 were observed in the 3rd, for LpPLA2 in the 4th ETP quartile. Conversely, hsCRP and SAA were highest in the 4th quartile. CONCLUSIONS: These results demonstrate that not the lowest ETP possible, but slightly higher levels are associated with a reduced risk of CVD and lower markers of endothelial dysfunction, suggesting a more complex role of thrombin in cardiovascular disease.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Medical Translational Research (J. Schneider Group)
Permalink :	http://hdl.handle.net/10993/27267
Commentary :	Copyright (c) 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

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