| Reference : Urinary C-peptide: A useful tool for evaluating the endogenous insulin reserve in coh... |
| Scientific journals : Article | |||
| Human health sciences : Multidisciplinary, general & others | |||
| http://hdl.handle.net/10993/27244 | |||
| Urinary C-peptide: A useful tool for evaluating the endogenous insulin reserve in cohort and longitudinal studies of diabetes in childhood | |
| English | |
De Beaufort, Carine  [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >] | |
| Den Boer, N. C. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands] | |
| Bruining, G. J. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands] | |
| Eilers, G. A. M. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands] | |
| Van Strik, R. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands] | |
| Weterings, T. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands] | |
| 1988 | |
| Annals of Clinical Biochemistry | |
| 25 | |
| 5 | |
| 552-559 | |
| Yes (verified by ORBilu) | |
| 00045632 | |
| [en] C-Peptide ; Child ; Cohort Studies ; Diabetes Mellitus, Insulin-Dependent ; Glucagon ; Glycosuria ; Human ; Insulin ; Ketone Bodies ; Longitudinal Studies | |
| [en] Increasing research into the remission phase of type I diabetes mellitus stresses the importance of a non-traumatic and reliable method for the evaluation of endogenous insulin production. We compared 24-h urinary C-peptide excretion (UCE) with plasma C-peptide values before and after stimulation with 1 mg glucagon in 24 type I diabetic children. Fasting plasma C-peptide values and stimulated plasma C-peptide values showed a linear correlation with 24 h UCE. Mean plasma C-peptide levels correlated inversely with the exogenous insulin dose. A slightly better correlation was found between the exogenous insulin dose and 24 h UCE. Control data of 24 h UCE were obtained from healthy siblings. A linear correlation with ages was found up to 10 years of age above which UCE values seem to reach a plateau. This effect of age, as well as the frequency of sampling was taken into account in the derivation of 95% reference intervals for UCE. The measurement of 24 h UCE appears to be a useful parameter to assess endogenous insulin production in diabetic children, provided that age is taken into account. | |
| http://hdl.handle.net/10993/27244 |
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