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Article (Scientific journals)
Decreased prevalence of atopic diseases in children with diabetes
De Beaufort, Carine
2000In Journal of Pediatrics, 137, p. 470-474
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Keywords :
atopic diseases; children; diabetes; risk; protection; type 1
Abstract :
[en] OBJECTIVE: To test the hypothesis that atopic diseases in early life are associated with a reduced risk (protection) for the development of type 1 diabetes in childhood. STUDY DESIGN: European centers (n = 8) with access to population-based type 1 diabetes registries (>90% degree of ascertainment) participated in a case control study focusing on early exposures and risk factors for type 1 diabetes. Altogether, data from 1028 members of a case group and 2744 members of a control group corresponding to 85.4% eligible members of the case group and 76.1% of the control group were analyzed. Information in this study was collected regarding atopic diseases (atopic eczema, allergic rhinoconjunctivitis, and asthma). RESULTS: Atopic disease and asthma particularly are associated with significant reductions in risk of childhood type 1 diabetes. The risk reduction associated with asthma was observed reasonably consistently among the 8 study centers, which represent a wide range of diabetes incidence. Risk reductions associated with all 3 expressions of atopy were particularly marked in children whose type 1 diabetes was diagnosed in the 10- to 14-year age group. CONCLUSION: These findings indicate that atopic conditions may be protective against the development of type 1 diabetes and are consistent with the immunologic concept of T(H)1 (type 1 diabetes) and T(H)2 (atopy) diseases being mutually exclusive.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Other collaborator :
De Beaufort, Carine ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Decreased prevalence of atopic diseases in children with diabetes
Publication date :
2000
Journal title :
Journal of Pediatrics
ISSN :
1097-6833
Publisher :
Mosby, St Louis, United States - Missouri
Volume :
137
Pages :
470-474
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Eurodiab Substudy 2 Study Group
Available on ORBilu :
since 14 May 2016

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