Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age
Gies, I.; Thomas, M.; Tenoutasse, S.et al.
2012 • In Hormone Research in Paediatrics, 78 (1), p. 24-30
insulin sensitivity; Growth Hormone; treatment; small children; SGA; gestational age
Abstract :
[en] AIM:
To study the relationship between insulin sensitivity and growth response in short children born small for gestational age (SGA) treated with growth hormone (GH).
METHODS:
Randomized, open-label, 24-month intervention study in 40 short prepubertal SGA children [age (mean ± SD) 5.3 ± 1.5 years], who either remained untreated (n = 20) or were treated with GH (66 µg/kg/day; n = 20). Changes in fasting glucose, insulin, quantitative insulin sensitivity check index (QUICKI), IGF-1 and leptin after 1 and 2 years were studied.
RESULTS:
Mean height SDS increased from -3.3 ± 0.7 to -2.3 ± 0.7 after 1 year, and to -1.9 ± 0.7 after 2 years of treatment. QUICKI decreased significantly (p = 0.008) in the first year of GH treatment and stabilized in the second year. Baseline QUICKI was positively associated (r = 0.40; p < 0.05) with the change in height SDS in the first year.
CONCLUSION:
Higher insulin sensitivity at the start of GH therapy is associated with greater first-year growth response to GH, and could be a promising parameter in selecting prepubertal short SGA children for GH treatment. However, this finding needs to be confirmed in larger studies.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Gies, I.
Thomas, M.
Tenoutasse, S.
De Waele, K.
Lebrethon, M.C.
Beckers, D.
Francois, I.
Maes, M.
Rooman, R.
De Beaufort, Carine ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Massa, G.
De Schepper, J.
External co-authors :
yes
Language :
English
Title :
Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age