Reference : Comparative genomic analysis of the hexuronate metabolism genes and their regulation ...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Comparative genomic analysis of the hexuronate metabolism genes and their regulation in gamma-proteobacteria
Suvorova, Inna A. []
Tutukina, Maria N. []
Ravcheev, Dmitry mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Rodionov, Dmitry A. []
Ozoline, Olga N. []
Gelfand, Mikhail S. []
Journal of Bacteriology
American Society for Microbiology (ASM)
Yes (verified by ORBilu)
[en] The hexuronate metabolism in Escherichia coli is regulated by two related transcription factors from the FadR subfamily of the GntR family, UxuR and ExuR. UxuR controls the d-glucuronate metabolism, while ExuR represses genes involved in the metabolism of all hexuronates. We use a comparative genomics approach to reconstruct the hexuronate metabolic pathways and transcriptional regulons in gammaproteobacteria. We demonstrate differences in the binding motifs of UxuR and ExuR, identify new candidate members of the UxuR/ExuR regulons, and describe the links between the UxuR/ExuR regulons and the adjacent regulons UidR, KdgR, and YjjM. We provide experimental evidence that two predicted members of the UxuR regulon, yjjM and yjjN, are the subject of complex regulation by this transcription factor in E. coli.

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10. Suvorova et al., 2011 (Hexuronates).pdfPublisher postprint1.74 MBView/Open

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