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25 April 2016
Article (Scientific journals)
A decade of metaproteomics: where we stand and what the future holds
Wilmes, Paul; Heintz, Anna; Bond, Philip
2015In Proteomics
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Keywords :
Integrated omics; Metagenomics; Metaproteomics; Microbial community; Microbial systems ecology
Abstract :
[en] We are living through exciting times during which we are able to unravel the “microbial dark matter” in and around us through the application of high-resolution “meta-omics”. Metaproteomics offers the ability to resolve the major catalytic units of microbial populations and thereby allows the establishment of genotype-phenotype linkages from in situ samples. A decade has passed since the term “metaproteomics” was first coined and corresponding analyses were carried out on mixed microbial communities. Metaproteomics has yielded many important insights into microbial ecosystem function in the various environmental settings where it has been applied. Although initial progress in analytical capacities and resulting numbers of proteins identified was extremely fast, this trend slowed rapidly. Here we highlight several representative metaproteomic investigations of activated sludge, acid mine drainage biofilms, freshwater and seawater microbial communities, soil, and human gut microbiota. By using these case studies, we highlight current challenges and possible solutions for metaproteomics to realize its full potential, i.e. to enable conclusive links between microbial community composition, physiology, function, interactions, ecology, and evolution.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group)
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Wilmes, Paul ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Heintz, Anna ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Bond, Philip;  University of Queensland > Advanced Water Management Centre
External co-authors :
Language :
Title :
A decade of metaproteomics: where we stand and what the future holds
Publication date :
Journal title :
Publisher :
Wiley-VCH Verlag Gmbh, Weinheim, Germany
Peer reviewed :
Peer Reviewed verified by ORBi


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