Sensitivity Analysis; Robustness; Model; Systems Biology
Disciplines :
Ingénierie, informatique & technologie: Multidisciplinaire, généralités & autres
Auteur, co-auteur :
PERUMAL, Thanneer Malai ; National University of Singapore > Chemical and Biomolecular Engineering
Gunawan, R.
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Impulse parametric sensitivity analysis
Date de publication/diffusion :
2011
Nombre de pages :
9686-9690
Nom de la manifestation :
18th IFAC World Congress
Organisateur de la manifestation :
IFAC
Lieu de la manifestation :
Milan, Italie
Date de la manifestation :
28-08-2011 to 2-09-2011
Manifestation à portée :
International
Références de l'abstract :
Complexity often limits human intuition in understanding system behavior, motivating the creation and analysis of mathematical models to understand these systems. One of the most commonly used analyses is the classical parametric sensitivity analysis (PSA), which maps out the parametric dependence of system behavior. In this article, we present a novel sensitivity analysis, called impulseparametric sensitivity analyses (iPSA), which is based on impulse perturbations to model parameters. Hence, the iPSA gives a step-by-step mechanistic insight on how a particular output behavior is accomplished and complementarily how (an impulse) perturbation propagates through the network. More specifically iPSA coefficients can reveal which parameters are essential and when they become important. The efficacy of this analysis is demonstrated on examples drawn from biology: the Fas-induced cell death model of human Jurkat T-cells.
