Lack of Polysomnographic Non-REM Sleep Changes in Early Parkinson’s Disease

Diederich, Nico; Rufra, Olivier; Pieri, Vannina; Hipp, Géraldine; Vaillant, Michel

doi:10.1002/mds.25520

Reference : Lack of Polysomnographic Non-REM Sleep Changes in Early Parkinson’s Disease


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/26500

Title :	Lack of Polysomnographic Non-REM Sleep Changes in Early Parkinson’s Disease
Language :	English
Author, co-author :	Diederich, Nico [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; Centre Hospitalier de Luxembourg > Department of Neuroscience > > ; Centre Hospitalier de Luxembourg > Interdisciplinary Sleep Laboratory]
	Rufra, Olivier [Centre Hospitalier de Luxembourg > Interdisciplinary Sleep Laboratory]
	Pieri, Vannina [Centre Hospitalier de Luxembourg > Department of Neuroscience]
	Hipp, Géraldine [Centre Hospitalier de Luxembourg > Department of Neuroscience]
	Vaillant, Michel [CRP-Santé > Methodology and Statistical Unit]
Publication date :	2013
Journal title :	Movement Disorders
Publisher :	Wiley Liss, Inc.
Peer reviewed :	Yes (verified by ORBi^lu)
ISSN :	0885-3185
e-ISSN :	1531-8257
City :	New York
Country :	NY
Keywords :	[en] Parkinson’s disease ; polysomnography ; REM sleep behavior disorder ; sleep ; sleep questionnaire
Abstract :	[en] Background: Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson’s disease (IPD). Methods: Thirty-three patients who had IPD with a disease duration 3 years and 37 age-matched controls were recruited. PSG analysis was performed on current medication. Results: Patients with IPD had a reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P < 0.05). Total sleep time, sleep efficiency, indices/hour of arousals, awakenings, apnea/hypopnea, and periodic leg movements were similar in both groups. Age, but not dopaminergic medication, had a negative impact on sleep architecture in patients with IPD. There was no correlation between sleep efficiency assessed by PSG and sleep quality assessed by questionnaire. Conclusions: The results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage. VC 2013 International Parkinson and Movement Disorder Society
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Permalink :	http://hdl.handle.net/10993/26500
DOI :	10.1002/mds.25520

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