Parkinson’s disease; polysomnography; REM sleep behavior disorder; sleep; sleep questionnaire
Abstract :
[en] Background: Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson’s disease (IPD).
Methods: Thirty-three patients who had IPD with a disease duration 3 years and 37 age-matched controls were recruited. PSG analysis was performed on current
medication.
Results: Patients with IPD had a reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P < 0.05). Total sleep time, sleep efficiency, indices/hour of arousals, awakenings, apnea/hypopnea, and periodic leg movements were similar in both groups. Age, but not dopaminergic medication, had a negative impact on sleep architecture in patients with IPD. There was no correlation between sleep efficiency assessed by PSG and sleep quality assessed by questionnaire.
Conclusions: The results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent
or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage. VC 2013 International Parkinson and Movement Disorder Society
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Diederich, Nico ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; Centre Hospitalier de Luxembourg > Department of Neuroscience ; Centre Hospitalier de Luxembourg > Interdisciplinary Sleep Laboratory
Rufra, Olivier; Centre Hospitalier de Luxembourg > Interdisciplinary Sleep Laboratory
Pieri, Vannina; Centre Hospitalier de Luxembourg > Department of Neuroscience
Hipp, Géraldine; Centre Hospitalier de Luxembourg > Department of Neuroscience
Vaillant, Michel; CRP-Santé > Methodology and Statistical Unit
External co-authors :
yes
Language :
English
Title :
Lack of Polysomnographic Non-REM Sleep Changes in Early Parkinson’s Disease
Publication date :
2013
Journal title :
Movement Disorders
ISSN :
1531-8257
Publisher :
Wiley Liss, Inc., New York, United States - New York