Reference : COEL: A Cloud-based Reaction Network Simulator
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Computer science
Computational Sciences
COEL: A Cloud-based Reaction Network Simulator
Banda, Peter mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Teuscher, Christof [> >]
Frontiers in Robotics and AI
[en] COEL ; chemical reaction network ; chemical modeling tool ; web tool ; computational grid ; DNA-strand displacement
[en] Chemical Reaction Networks (CRNs) are a formalism to describe the macroscopic behavior of chemical systems. We introduce COEL, a web- and cloud-based CRN simulation framework, which does not require a local installation, runs simulations on a large computational grid, provides reliable database storage, and offers a visually pleasing and intuitive user interface. We present an overview of the underlying software, the technologies, and the main architectural approaches employed. Some of COEL’s key features include ODE-based simulations of CRNs and multicompartment reaction networks with rich interaction options, a built-in plotting engine, automatic DNA-strand displacement transformation and visualization, SBML/Octave/Matlab export, and a built-in genetic-algorithm-based optimization toolbox for rate constants. COEL is an open-source project hosted on GitHub (, which allows interested research groups to deploy it on their own sever. Regular users can simply use the web instance at no cost at The framework is ideally suited for a collaborative use in both research and education.

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