Reference : Blood flow simulation using smoothed particle hydrodynamics: application to thrombus ...

	Document type :	Scientific congresses, symposiums and conference proceedings : Unpublished conference
	Discipline(s) :	Engineering, computing & technology : Multidisciplinary, general & others
	Focus Areas :	Computational Sciences
	To cite this reference:	http://hdl.handle.net/10993/26375

Title :	Blood flow simulation using smoothed particle hydrodynamics: application to thrombus generation
Language :	English
Author, co-author :	AL-SAAD, Mohammed [Cardiff University]
	Kulasegaram, Sivakumar [Cardiff University]
	Bordas, Stéphane [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Engineering Research Unit >]
Publication date :	31-Mar-2016
Peer reviewed :	Yes
On invitation :	No
Audience :	International
Event name :	ACME 2016 - UK Association for Computational Methods in Engineering
Event date :	March 31-April 1, 2016
Event organizer :	Cardiff University
Event place (city) :	Cardiff
Event country :	Wales
Keywords :	[en] blood flow ; SPH ; thrombus
Abstract :	[en] Blood flow rheology is considered to be a complex phenomenon. In order to understand the characteristics of blood flow, it is important to identify key parameters those influence the flow behaviour of blood. Further, the characterisation of blood flow will also enable us to understand flow parameters associated with physiological conditions such as atherosclerosis. Thrombosis plays a crucial role in atherosclerosis, or to stop bleeding when a blood vessel is injured. This article focuses on using meshless particle-based Lagrangian numerical technique named smoothed particles hydrodynamic (SPH) method to study the flow behaviour of blood and to explore flow condition that induces formation of thrombus in a blood vessel. Due its simplicity and effectiveness, the SPH method is employed here to simulate the process of thrombogenesis under the influence of various blood flow parameters. In the present SPH simulation, blood is modelled by particles that have characteristics of plasma and of platelets. To simulate coagulation of platelets which forms thrombus, the adhesion and aggregation process of platelets are modelled by an effective inter-particle force model. With these models, platelet motion in the flowing blood and platelet adhesion and aggregation are effectively coupled with viscous blood flow. In this study, the adhesion and aggregation of blood particles are performed on a bifurcated artery under a various low Reynolds number scenarios. The results are compared with experimental results and a good agreement is found between the simulated and experimental results.
Funders :	Iraqi government
Target :	Researchers ; Professionals ; Students ; Others
Permalink :	http://hdl.handle.net/10993/26375
Framework Programme / European Project :	FP7 ; 279578 - REALTCUT - Towards real time multiscale simulation of cutting in non-linear materials with applications to surgical simulation and computer guided surgery

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