Reference : The hallmarks of Parkinson's disease.

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/2601

Title :	The hallmarks of Parkinson's disease.
Language :	English
Author, co-author :	Antony, Paul [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Diederich, Nico [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Krüger, Rejko [University of Tuebingen > Center of Neurology and Hertie-Institute for Clinical Brain Research]
	Balling, Rudi [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Publication date :	9-May-2013
Journal title :	FEBS Journal
Publisher :	Blackwell Publishing
Pages :	13
Peer reviewed :	Yes
Audience :	International
ISSN :	1742-464X
City :	Oxford
Country :	United Kingdom
Keywords :	[en] cellular hallmarks ; Parkinson’s disease ; systems biology
Abstract :	[en] Since the discovery of dopamine as a neurotransmitter in the 1950s, Parkinson's disease (PD) research has generated a rich and complex body of knowledge, revealing PD to be an age-related multifactorial disease, influenced by both genetic and environmental factors. The tremendous complexity of the disease is increased by a non-linear progression of the pathogenesis between molecular, cellular, and organic systems. In this mini-review, we explore the complexity of PD and propose a systems-based approach, organizing the available information around cellular disease hallmarks. We encourage our peers to adopt this cell-based view with the aim of improving communication in interdisciplinary research endeavors targeting the molecular events, modulatory cell-to-cell signaling pathways, and emerging clinical phenotypes related to PD. This article is protected by copyright. All rights reserved.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Target :	Researchers ; Professionals ; Students ; General public ; Others
Permalink :	http://hdl.handle.net/10993/2601
DOI :	10.1111/febs.12335
Other URL :	http://onlinelibrary.wiley.com/doi/10.1111/febs.12335/pdf
Commentary :	This article is protected by copyright. All rights reserved.

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