Reference : Bee venom and its component apamin as neuroprotective agents in a Parkinson disease m...
Scientific journals : Article
Scientific journals : Article
Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.
Alvarez-Fischer, Daniel [> >]
Noelker, Carmen [> >]
Vulinovic, Franca [> >]
Grünewald, Anne [> >]
Chevarin, Caroline [> >]
Klein, Christine [> >]
Oertel, Wolfgang H. [> >]
Hirsch, Etienne C. [> >]
Michel, Patrick P. [> >]
Hartmann, Andreas [> >]
PloS one
Yes (verified by ORBilu)
United States
[en] Acupuncture Points ; Animals ; Apamin/pharmacology ; Bee Venoms/pharmacology ; Behavior, Animal/drug effects ; Corpus Striatum/drug effects/metabolism ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Exploratory Behavior/drug effects ; MPTP Poisoning/prevention & control ; Male ; Mice ; Mice, Inbred C57BL ; Neuroprotective Agents/pharmacology ; Parkinson Disease/prevention & control ; Tumor Necrosis Factor-alpha/metabolism
[en] Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. However, no information regarding a potential protective action of apamin in animal models of PD is available to date. The specific goals of the present study were to (i) establish that the protective effect of bee venom for dopaminergic neurons is not restricted to acupoint stimulation, but can also be observed using a more conventional mode of administration and to (ii) demonstrate that apamin can mimic the protective effects of a bee venom treatment on dopaminergic neurons. Using the chronic mouse model of MPTP/probenecid, we show that bee venom provides sustained protection in an animal model that mimics the chronic degenerative process of PD. Apamin, however, reproduced these protective effects only partially, suggesting that other components of bee venom enhance the protective action of the peptide.
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