Reference : The role of IP3R clustering in Ca2+ signaling.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
The role of IP3R clustering in Ca2+ signaling.
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Falcke, Martin [> >]
Genome informatics. International Conference on Genome Informatics
Yes (verified by ORBilu)
[en] Animals ; Calcium/physiology ; Calcium-Transporting ATPases/metabolism ; Cytosol/physiology ; Endoplasmic Reticulum/physiology ; Inositol 1,4,5-Trisphosphate Receptors/physiology ; Ion Channels/physiology ; Probability ; Signal Transduction
[en] Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca(2+) into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate receptor (IP(3)R), which is activated by IP(3) and Ca(2+) itself leading to Ca(2+) induced Ca(2+) release (CICR). We have shown in an experimental study, that Ca(2+) oscillations are sequences of random spikes that occur by wave nucleation. We use here our recently developed model for Ca(2+) dynamics in 3 dimension to illuminate the role of IP(3)R clustering within spatial extended systems.

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