Reference : How does intracellular Ca2+ oscillate: by chance or by the clock?
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
How does intracellular Ca2+ oscillate: by chance or by the clock?
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Kettenmann, Helmut [> >]
Winkler, Ulrike [> >]
Wartenberg, Maria [> >]
Sauer, Heinrich [> >]
Tovey, Stephen C. [> >]
Taylor, Colin W. [> >]
Falcke, Martin [> >]
Biophysical journal
Yes (verified by ORBilu)
United States
[en] Action Potentials ; Animals ; Biophysics/methods ; Calcium/metabolism ; Calcium Signaling ; Cell Membrane/metabolism ; Diffusion ; Electrophysiology/methods ; Humans ; Models, Biological ; Neurons ; Oscillometry ; Stochastic Processes
[en] Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free Ca2+ using Ca2+ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular Ca2+ oscillations with small standard deviation of ISIs.

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